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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prevalence of p16 expression in oropharyngeal squamous cell carcinoma in southern Brazil

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Author(s):
Girardi, Fabio Muradas [1] ; Wagner, Vivian P. [2] ; Martins, Manoela Domingues [2, 3, 4] ; Abentroth, Aliende Lengler [1] ; Hauth, Luiz Alberto [1]
Total Authors: 5
Affiliation:
[1] Ana Nery Hosp, Integrated Oncol Ctr, Santa Cruz Do Sul, RS - Brazil
[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil
[3] Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, RS - Brazil
[4] Porto Alegre Clin Hosp HCPA UFRGS, Dept Oral Med, Porto Alegre, RS - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 130, n. 6, p. 681-691, DEC 2020.
Web of Science Citations: 0
Abstract

Objective. Our aim was to evaluate the prevalence of human papillomavirus (HPV)-positive tumors in a cohort of patients with oropharyngeal squamous cell carcinoma (OPSCC) at a single center in southern Brazil and determine the short-term prognostic factors in this sample. Study Design. Ninety-one consecutive patients with newly diagnosed primary OPSCC between January 2017 and December 2019 were retrospectively included. Demographic, clinical, pathologic, and survival data were collected. HPV status was determined by using p16 immunohistochemistry. Results. The overall prevalence of HPV-positive (HPV+) OPSCC was 20.9%. Patients with HPV+ tumors presented a nodal metastasis as the first clinical sign (P =.02); reported less alcohol (P <.001) and tobacco use (P <.001); exhibited lower tumor stages (P <.001) and higher microscopic grades (P =.01); and had higher chances of having resectable tumors (P =.008). p16-negative status (P =.01); unresectable/inoperable tumors (P <.001); presence of nodal metastasis (P =.005); and higher American Joint Committee on Cancer (AJCC) stage (P =.002) were significantly associated with worse disease-specific survival. Conclusions. The prevalence of HPV+ OPSCC in southern Brazil is relatively low, and p16-positive status was associated with Better prognosis. Higher AJCC stage, nodal metastasis, and unresectability/inoperability were associated with the highest hazard ratios for death resulting from OPSCC. (AU)

FAPESP's process: 16/21785-4 - Association of BDNF/TRKB signaling pathway with tumor agressiveness and cancer stem cell profile of malignant salivary gland tumors
Grantee:Vivian Petersen Wagner
Support Opportunities: Scholarships in Brazil - Post-Doctoral