The Possible Importance of Glutamine Supplementation to Mood and Cognition in Hypoxia from High Altitude

Autor(es)

Dos Santos Quaresma, M. V. L. ^[1] ; Souza, W. Y. G. ^[2] ; Lemos, V. A. ^[2] ; Caris, V, A. ; Thomatieli-Santos, V, R.

Afiliação do(s) autor(es)

^[1] V, Ctr Univ Sao Camilo, Dept Nutr, BR-04263200 Sao Paulo - Brazil

^[2] V, Univ Fed Sao Paulo, Dept Biosci, BR-11015020 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NUTRIENTS; v. 12, n. 12 DEC 2020.
• Citações Web of Science: 0

Resumo

Hypoxia induced by low O-2 pressure is responsible for several physiological and behavioral alterations. Changes in physiological systems are frequent, including inflammation and psychobiological declines such as mood and cognition worsening, resulting in increased reaction time, difficulty solving problems, reduced memory and concentration. The paper discusses the possible relationship between glutamine supplementation and worsening cognition mediated by inflammation induced by high altitude hypoxia. The paper is a narrative literature review conducted to verify the effects of glutamine supplementation on psychobiological aspects. We searched MEDLINE/PubMed and Web of Science databases and gray literature by Google Scholar for English articles. Mechanistic pathways mediated by glutamine suggest potential positive effects of its supplementation on mood and cognition, mainly its potential effect on inflammation. However, clinical studies are scarce, making any conclusions impossible. Although glutamine plays an important role and seems to mitigate inflammation, clinical studies should test this hypothesis, which will contribute to a better mood and cognition state for several people who suffer from problems mediated by hypoxia. (AU)

• Processo FAPESP: 17/26563-2 - Efeitos da suplementação com carboidrato e glutamina sobre parâmetros da resposta immune inata e inflamação durante e após exercício na hipóxia
• Beneficiário: Ronaldo Vagner Thomatieli dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular