| Full text | |
| Author(s): |
Dos Santos Quaresma, M. V. L.
[1]
;
Souza, W. Y. G.
[2]
;
Lemos, V. A.
[2]
;
Caris, V, A.
;
Thomatieli-Santos, V, R.
Total Authors: 5
|
| Affiliation: | [1] V, Ctr Univ Sao Camilo, Dept Nutr, BR-04263200 Sao Paulo - Brazil
[2] V, Univ Fed Sao Paulo, Dept Biosci, BR-11015020 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | NUTRIENTS; v. 12, n. 12 DEC 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Hypoxia induced by low O-2 pressure is responsible for several physiological and behavioral alterations. Changes in physiological systems are frequent, including inflammation and psychobiological declines such as mood and cognition worsening, resulting in increased reaction time, difficulty solving problems, reduced memory and concentration. The paper discusses the possible relationship between glutamine supplementation and worsening cognition mediated by inflammation induced by high altitude hypoxia. The paper is a narrative literature review conducted to verify the effects of glutamine supplementation on psychobiological aspects. We searched MEDLINE/PubMed and Web of Science databases and gray literature by Google Scholar for English articles. Mechanistic pathways mediated by glutamine suggest potential positive effects of its supplementation on mood and cognition, mainly its potential effect on inflammation. However, clinical studies are scarce, making any conclusions impossible. Although glutamine plays an important role and seems to mitigate inflammation, clinical studies should test this hypothesis, which will contribute to a better mood and cognition state for several people who suffer from problems mediated by hypoxia. (AU) | |
| FAPESP's process: | 17/26563-2 - Effects of carbohydrate and glutamine supplementation on parameters of innate immune response and inflammation during and after exercise in hypoxia |
| Grantee: | Ronaldo Vagner Thomatieli dos Santos |
| Support Opportunities: | Regular Research Grants |