Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology

Autor(es)

Araldi, Rodrigo Pinheiro ^{[1, 2, 3]} ; D'Amelio, Fernanda ^[1] ; Vigerelli, Hugo ^[1] ; de Melo, Thatiana Correa ^[1] ; Kerkis, Irina ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Inst Butantan, Genet Lab, 1500 Vital Brasil St, BR-05503900 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Pauloa UNIFESP, Escola Paulista Med EPM, Programa Posgrad Endocrinol & Metabol, BR-04021001 Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med EPM, Programa Posgrad Biol Estrutural & Func, BR-04021001 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLS; v. 9, n. 12 DEC 2020.
• Citações Web of Science: 0

Resumo

The aging population has contributed to the rapid rise in the global incidence of neurodegenerative diseases. Despite the medical advances, there are no effective treatments for these disorders. Therefore, there is an urgent need for new treatments for these diseases. In this sense, cell therapy has been recognized as the best candidate for treating incurable diseases, such as neurodegenerative disorders. However, the therapeutic use of these cells can be limited by several factors. Thus, there has been a rediscovery that extracellular vesicles, including exosomes, can be alternatively explored in the treatment of these diseases, overcoming the limits of cell-based therapy. In this sense, this review aims to revisit all areas from biology, including biogenesis and the content of exosomes, to biotechnology, proposing the minimal information required to isolate, characterize, and study the content of these vesicles for scientific and/or clinical purposes. (AU)

• Processo FAPESP: 10/51051-6 - Células-tronco adultas versus células tronco pluripotentes induzidas
• Beneficiário: Irina Kerkis
• Modalidade de apoio: Auxílio à Pesquisa - Temático