A comparison of developmental toxicity of brominated and halogen-free flame retardant on zebrafish

Autor(es)

Abe, Flavia Renata ^[1] ; Soares de Oliveira, Andreia Avila ^[1] ; Marino, Renan Vieira ^[1] ; Rizzi Rialto, Taisa Carla ^[1] ; Oliveira, Danielle Palma ^[1] ; Dorta, Daniel Junqueira ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Food Sci, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY; v. 208, JAN 15 2021.
• Citações Web of Science: 4

Resumo

Brominated diphenyl ethers (BDEs) are halogenated flame retardants. Several concerns related to persistence and toxicity of BDEs have been resulted in a growing need of BDEs replacement. The use of halogen-free flame retardants (HFFR) has increased as a safer alternative, but little information is available on their toxic potential for environmental health and for developing organisms. Therefore, the aim of this study was to evaluate and compare the toxicity of three congeners of BDEs (BDE-47, BDE-99 and BDE-154) with an HFFR (aluminum diethylphosphinate, ALPI) on zebrafish (Danio rerio) by assessing endpoints of lethality, sub-lethality and teratogenicity at the earlier stages of development. The highest tested concentration of BDE-47 (12.1 mg/L) induced pericardium and yolk sac edemas that first appeared at 48 h post-fertilization (hpf) and then were mostly reabsorbed until 144 hpf. BDE-47 also showed a slight but non-significant tendency to affect swim bladder inflation. The rate of edemas increased in a concentration-dependent manner after exposure to BDE-99, but there were no significant differences. In addition, the congener BDE-99 also presented a slight and non-significant effect on swim bladder inflation, but only at the highest concentration tested. Regarding BDE-154 exposure, the rate of edemas and swim bladder inflation were not affected. Finally, in all ALPI exposure concentrations (0.003 up to 30 mg/L), no sub-lethal or teratogenic effects were observed on developing organisms until 96 hpf. Although further studies are needed, our results demonstrate that when comparing the developmental toxicity induced by flame retardants in zebrafish, the HFFR ALPI may be considered a more suitable alternative to BDE-47. (AU)

• Processo FAPESP: 14/50945-4 - INCT 2014: Instituto Nacional de Tecnologias Alternativas para Detecção, Avaliação Toxicológica e Remoção de Micropoluentes e Radioativos
• Beneficiário: Maria Valnice Boldrin
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/01509-4 - Avaliação dos efeitos letais, sub-letais, teratogênicos e genotóxicos de corantes têxteis sobre o desenvolvimento êmbrio-larval de zebrafish (Danio rerio)
• Beneficiário: Danielle Palma de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/24298-2 - Utilização de estratégia de multi-biomarcadores em zebrafish como plataforma para estimar os efeitos neurocomportamentais induzidos por retardantes de chama
• Beneficiário: Danielle Palma de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/03281-9 - Análises de alta performance (high-throughput screening) para avaliação da toxicidade neurocomportamental e no desenvolvimento induzidas após a exposição de embriões de zebrafish a contaminantes emergentes
• Beneficiário: Danielle Palma de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular