Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study

Autor(es)

dos Santos, Alexandre Moura ^[1] ; Misse, Rafael Giovani ^[1] ; Borges, Isabela Bruna Pires ^[1] ; Gualano, Bruno ^[1] ; de Souza, Alexandre Wagner Silva ^[2] ; Takayama, Liliam ^[1] ; Pereira, Rosa Maria R. ^[1] ; Shinjo, Samuel Katsuyuki ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Div Rheumatol, Fac Med FMUSP, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Div Rheumatol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ADVANCES IN RHEUMATOLOGY; v. 61, n. 1 JAN 8 2021.
• Citações Web of Science: 0

Resumo

Background: Modifiable cardiovascular risk factors (MCRFs), such as those related to aerobic capacity, muscle strength, physical activity, and body composition, have been poorly studied in Takayasu arteritis (TAK). Therefore, the aim of the study was to investigate MCRFs and their relationships with disease status and comorbidities among patients with TAK. Methods: A multicenter cross-sectional study was conducted between 2019 and 2020, in which 20 adult women with TAK were compared with 16 healthy controls matched by gender, age, and body mass index. The following parameters were analyzed: aerobic capacity by cardiopulmonary test; muscle function by timed-stands test, timed up-and-go test, and handgrip test; muscle strength by one-repetition maximum test and handgrip test; body composition by densitometry; physical activity and metabolic equivalent by IPAQ, quality of life by HAQ and SF-36; disease activity by ITAS2010 and NIH score; and presence of comorbidities. Results: Patients with TAK had a mean age of 41.5 (38.0-46.3) years, disease duration of 16.0 (9.5-20.0) years, and a mean BMI of 27.7 +/- 4.5 kg/m(2). Three out of the 20 patients with TAK had active disease. Regarding comorbidities, 16 patients had systemic arterial hypertension, 11 had dyslipidemia, and two had type 2 diabetes mellitus, while the control group had no comorbidities. TAK had a significant reduction in aerobic capacity (absolute and relative VO2 peak), muscle strength in the lower limbs, increased visceral adipose tissue, waist-to-hip ratio, reduced walking capacity, decreased weekly metabolic equivalent, and quality of life (P< 0.05) as compared to controls. However, there were no correlations between these MCRFs parameters and disease activity. Conclusions: TAK show impairment in MCRFs; therefore, strategies able to improve MCRF should be considered in this disease. (AU)

• Processo FAPESP: 18/08735-3 - Capacidade aeróbia e exercício de força na arterite de Takayasu: relações e impactos nos desfechos clínicos, laboratoriais e extensão das lesões vasculares
• Beneficiário: Alexandre Moura dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 19/11367-9 - Análise molecular e metabólica da Atorvastatina nos tecidos musculares de pacientes com Miopatias Autoimunes Sistêmicas
• Beneficiário: Isabela Bruna Pires Borges
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/12155-5 - Relevância e segurança da neuromodulação cerebral não-invasiva em pacientes com miopatias autoimunes sistêmicas: estudo duplo cego, randomizado e sham-controlado
• Beneficiário: Rafael Giovani Misse
• Modalidade de apoio: Bolsas no Brasil - Doutorado