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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy

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Autor(es):
Uscategui, Ricardo A. R. [1, 2] ; Barros, Felipe F. P. C. [3] ; Almeida, Vivian T. [2] ; Kawanami, Aline E. [2] ; Feliciano, Marcus A. R. [4] ; Vicente, Wilter R. R. [2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Fed Univ Jequithonha & Mucury Valleys UFVJM, Inst Agr Sci, Unai, MG - Brazil
[2] Sao Paulo State Univ Unesp Julio de Mesquita Filh, Dept Vet Pathobiol & Theriogenol, Jaboticabal, SP - Brazil
[3] Fed Rural Univ Rio de Janeiro UFRRJ, Dept Med & Vet Surg, Seropedica, RJ - Brazil
[4] Fed Univ Santa Maria UFSM, Dept Large Anim Clin, Santa Maria, RS - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: VETERINARY ANAESTHESIA AND ANALGESIA; v. 48, n. 1, p. 82-91, JAN 2021.
Citações Web of Science: 0
Resumo

Objective To evaluate the efficacy and cardiopulmonary effects of ketamine-midazolam for chemical restraint, isoflurane anesthesia and tramadol or methadone as preventive analgesia in spotted pacas subjected to laparoscopy. Study design Prospective placebo-controlled blinded trial. Animals A total of eight captive female Cuniculus paca weighing 9.3 +/- 0.9 kg. Methods Animals were anesthetized on three occasions with 15 day intervals. Manually restrained animals were administered midazolam (0.5 mg kg(-1)) and ketamine (25 mg kg(-1)) intramuscularly. Anesthesia was induced and maintained with isoflurane 30 minutes later. Tramadol (5 mg kg(-1)), methadone (0.5 mg kg(-1)) or saline (0.05 mL kg(-1)) were administered intramuscularly 15 minutes prior to laparoscopy. Heart rate (HR), respiratory rate, mean arterial pressure (MAP), peripheral oxygen saturation (SpO(2)), end-tidal CO2 partial pressure (PE'CO2), end-tidal concentration of isoflurane (FE'Iso), pH, PaO2, PaCO2, bicarbonate (HCO3-), anion gap (AG) and base excess (BE) were monitored after chemical restraint, anesthesia induction and at different laparoscopy stages. Postoperative pain was assessed by visual analog scale (VAS) for 24 hours. Variables were compared using ANOVA or Friedman test (p < 0.05). Results Chemical restraint was effective in 92% of animals. Isoflurane anesthesia was effective; however, HR, MAP, pH and AG decreased, whereas PE'CO2, PaO2, PaCO2, HCO3- and BE increased. MAP was stable with tramadol and methadone treatments; HR, FE'Iso and postoperative VAS decreased. VAS was lower for a longer time with methadone treatment; SpO(2) and AG decreased, whereas PE'CO2, PaCO2 and HCO3- increased. Conclusions and clinical relevance Ketamine-midazolam provided satisfactory restraint. Isoflurane anesthesia for laparoscopy was effective but resulted in hypotension and respiratory acidosis. Tramadol and methadone reduced isoflurane requirements, provided postoperative analgesia and caused hypercapnia, with methadone causing severe respiratory depression. Thus, the anesthetic protocol is adequate for laparoscopy in Cuniculus paca; however, methadone should be avoided. (AU)

Processo FAPESP: 12/00724-6 - ASPIRAÇÃO FOLICULAR POR VIDEOLAPAROSCOPIA E MATURAÇÃO OOCITÁRIA IN VITRO EM PACAS (Cuniculus paca - Linnaeus, 1766) MANTIDAS EM CATIVEIRO
Beneficiário:Felipe Farias Pereira da Câmara Barros
Modalidade de apoio: Bolsas no Brasil - Doutorado