Kefir reduces nitrosative stress and upregulates Nrf2 in the kidney of diabetic rats

Autor(es)

Pugliero, Samuel ^{[1, 2]} ; Lima, Deyse Yorgos ^{[2, 3]} ; Rodrigues, Adelson Marcal ^{[2, 3]} ; Bittencourt Bogsan, Cristina Stweart ^[4] ; Rogero, Marcelo Macedo ^[5] ; Punaro, Giovana Rita ^{[1, 2]} ; Suemitsu Higa, Elisa Mieko ^{[1, 2, 6, 3]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Nephrol, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Lab Nitr Oxide & Oxidat Stress, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Emergency Div, Translat Med, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Fac Pharmaceut Sci FCF, Dept Biochem & Pharmaceut Technol, Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Publ Hlth Coll FSP, Dept Nutr, Sao Paulo - Brazil

^[6] Univ Fed Sao Paulo UNIFESP, Emergency Div, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL DAIRY JOURNAL; v. 114, MAR 2021.
• Citações Web of Science: 0

Resumo

The aim was to analize whether Kefir activates nuclear erythroid 2-related factor 2 (Nrf2) under hyperglycaemic conditions in the kidneys of diabetic rats (DM). DM received kefir for 8 weeks (DMK group). There was a significant reduction in water and chow intake, reduction in diuresis and glycaemia in DMK versus DM, the protein levels of catalase (CAT), superoxide dismutase-1 (SOD-1) and Nrf2 were significantly increased and 3-nitrotyrosine (3-NT) was significantly reduced. Glycaemia had a moderate correlation with NO or superoxide anion and a strong correlation with 3-NT. Kefir improved the metabolic profile, reducing blood glucose and increasing the concentration of Nrf2, modulating CAT and SOD-1 in the renal cortex of diabetic animals, thus contributing to reduced oxidative/nitrosative stress in these animals. These data suggest that kefir could be used as an additional therapy to improve glycaemic control and restore antioxidant defence in the progression of diabetic nephropathy. (C) 2020 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 11/06286-8 - Efeito da ingestão de Kefir sobre a função de macrófagos peritoneais e da mucosa intestinal de ratos diabéticos
• Beneficiário: Elisa Mieko Suemitsu Higa
• Modalidade de apoio: Auxílio à Pesquisa - Regular