Acute physical exercise increases PI3K-p110 alpha protein content in the hypothalamus of obese mice

Autor(es)

Gaspar, Rafael C. ^[1] ; Nakandakari, Susana C. B. R. ^[2] ; Munoz, Vitor R. ^[1] ; Vieira, Renan F. L. ^[1] ; da Silva, Adelino S. R. ^[3] ; Cintra, Dennys E. ^{[4, 2]} ; de Moura, Leandro P. ^{[1, 4, 5]} ; Ropelle, Eduardo R. ^{[1, 4, 5]} ; Pauli, Jose Rodrigo ^{[1, 4, 5]}

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Lab Mol Biol Exercise, Limeira - Brazil

^[2] Univ Campinas UNICAMP, Lab Nutr Gen, Limeira - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto - Brazil

^[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Lab Cell Signaling, Campinas - Brazil

^[5] Univ Campinas UNICAMP, Sch Appl Sci, CEPECE Ctr Res Sport Sci, Limeira - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Anatomy; v. 238, n. 3, p. 743-750, MAR 2021.
• Citações Web of Science: 0

Resumo

The anatomy of the hypothalamus includes many nuclei and a complex network of neurocircuits. In this context, some hypothalamic nuclei reside closer to the blood-brain barrier, allowing communication with the peripheral organs through some molecules, such as leptin. Leptin is considered the main adipokine for energy homeostasis control. Furthermore, leptin signalling in the hypothalamus can communicate with insulin signalling through the activation of phosphoinositide 3-kinase (PI3k). Previous data suggest that isoforms of PI3k are necessary to mediate insulin action in the hypothalamus. However, obese animals show impairment in the central signalling of these hormones. Thus, in the current study, we evaluated the role of acute exercise in the leptin and insulin pathways in the hypothalamus, as well as in food intake control in obese mice. Although acute physical exercise was not able to modulate leptin signalling, this protocol suppressed the increase in the suppressor of cytokine signalling 3 (SOCS3) protein levels. In addition, acute exercise increased the content of PI3k-p110 alpha protein in the hypothalamus. The exercised animals showed a strong tendency to reduction in cumulative food intake. For the first time, our results indicate physical exercise can increase PI3k-p110 alpha protein content in the hypothalamus of obese mice and regulate food intake. (AU)

• Processo FAPESP: 17/20542-3 - Papel do exercício físico na regulação da proteína Notch1 em camundongos obesos: efeitos sobre a lipogênese e gliconeogênese hepática
• Beneficiário: Rafael Calais Gaspar
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/07568-6 - Efeitos do exercício físico sobre a via de sinalização da proteína Rock e regulação da lipogênese e gliconeogênese no fígado de ratos envelhecidos.
• Beneficiário: Vitor Rosetto Muñoz
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/20872-6 - Efeitos do exercício físico sobre a via de sinalização da proteína Rock e regulação da lipogênese e gliconeogênese no fígado de ratos envelhecidos
• Beneficiário: José Rodrigo Pauli
• Modalidade de apoio: Auxílio à Pesquisa - Regular