Convergent evolution of pain-inducing defensive venom components in spitting cobras

Autor(es):Mostrar menos -

Kazandjian, T. D. ^[1] ; Petras, D. ^{[2, 3]} ; Robinson, S. D. ^{[4, 5]} ; van Thiel, J. ^[6] ; Greene, H. W. ^[7] ; Arbuckle, K. ^[8] ; Barlow, A. ^{[9, 10]} ; Carter, D. A. ^[4] ; Wouters, R. M. ^[6] ; Whiteley, G. ^[1] ; Wagstaff, S. C. ^{[1, 11]} ; Arias, A. S. ^[12] ; Albulescu, L-O ^[1] ; Laing, A. Plettenberg ^[10] ; Hall, C. ^[10] ; Heap, A. ^[10] ; Penrhyn-Lowe, S. ^[10] ; McCabe, V, C. ; Ainsworth, S. ^[1] ; Silva, R. R. ^{[3, 13]} ; Dorrestein, P. C. ^[3] ; Richardson, M. K. ^[6] ; Gutierrez, J. M. ^[12] ; Calvete, J. J. ^[14] ; Harrison, R. A. ^[1] ; Vetter, I ^{[4, 15]} ; Undheim, E. A. B. ^{[4, 5, 16, 17]} ; Wuester, W. ^[10] ; Casewell, N. R. ^[1]

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^[1] Univ Liverpool Liverpool Sch Trop Med, Ctr Snakebite Res & Intervent, Liverpool L3 5QA, Merseyside - England

^[2] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 - USA

^[3] Univ Calif San Diego, Collaborat Mass Spectrometry Innovat Ctr, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 - USA

^[4] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072 - Australia

^[5] Univ Queensland, Ctr Adv Imaging, St Lucia, Qld 4072 - Australia

^[6] Leiden Univ, Inst Biol, NL-2333 BE Leiden - Netherlands

^[7] Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14853 - USA

^[8] Swansea Univ, Coll Sci, Dept Biosci, Swansea SA2 8PP, W Glam - Wales

^[9] Nottingham Trent Univ, Sch Sci & Technol, Nottingham NG11 8NS - England

^[10] Bangor Univ, Sch Nat Sci, Mol Ecol & Fisheries Genet Lab, Bangor LL57 2UW, Gwynedd - Wales

^[11] Univ Liverpool Liverpool Sch Trop Med, Res Comp Unit, Liverpool L3 5QA, Merseyside - England

^[12] Univ Costa Rica, Fac Microbiol, Inst Clodomiro Picado, San Jose 11501 - Costa Rica

^[13] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Mol Sci Dept, Nucleo Pesquisa Prod Nat & Sintet NPPNS, Ribeirao Preto - Brazil

^[14] CSIC, Evolutionary & Translat Ven Lab, Valencia 46010 - Spain

^[15] Univ Queensland, Sch Pharm, Woolloongabba, Qld 4102 - Australia

^[16] Norwegian Univ Sci & Technol, Ctr Biodivers Dynam, Dept Biol, N-7491 Trondheim - Norway

^[17] Univ Oslo, Ctr Ecol & Evolutionary Synth, Dept Biosci, N-0316 Oslo - Norway

• Tipo de documento: Artigo Científico
• Fonte: Science; v. 371, n. 6527, p. 386+, JAN 22 2021.
• Citações Web of Science: 17

Resumo

Convergent evolution provides insights into the selective drivers underlying evolutionary change. Snake venoms, with a direct genetic basis and clearly defined functional phenotype, provide a model system for exploring the repeated evolution of adaptations. While snakes use venom primarily for predation, and venom composition often reflects diet specificity, three lineages of cobras have independently evolved the ability to spit venom at adversaries. Using gene, protein, and functional analyses, we show that the three spitting lineages possess venoms characterized by an up-regulation of phospholipase A(2) (PLA(2)) toxins, which potentiate the action of preexisting venom cytotoxins to activate mammalian sensory neurons and cause enhanced pain. These repeated independent changes provide a fascinating example of convergent evolution across multiple phenotypic levels driven by selection for defense. (AU)

• Processo FAPESP: 19/05026-4 - Desenvolvimento de uma plataforma computacional modular extensível para análises de experimentos de metabolômica e metagenômica: Inovando com a descoberta de novas atividades enzimáticas e produtos naturais de interesse farmacêutico derivados
• Beneficiário: Ricardo Roberto da Silva
• Modalidade de apoio: Bolsas no Brasil - Programa BIOTA - Jovens Pesquisadores
• Processo FAPESP: 17/18922-2 - Desenvolvimento de uma plataforma computacional modular extensível para análises de experimentos de metabolômica e metagenômica: inovando com a descoberta de novas atividades enzimáticas e produtos naturais de interesse farmacêutico derivados
• Beneficiário: Ricardo Roberto da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Jovens Pesquisadores