| Full text | |
| Author(s): Show less - |
Kazandjian, T. D.
[1]
;
Petras, D.
[2, 3]
;
Robinson, S. D.
[4, 5]
;
van Thiel, J.
[6]
;
Greene, H. W.
[7]
;
Arbuckle, K.
[8]
;
Barlow, A.
[9, 10]
;
Carter, D. A.
[4]
;
Wouters, R. M.
[6]
;
Whiteley, G.
[1]
;
Wagstaff, S. C.
[1, 11]
;
Arias, A. S.
[12]
;
Albulescu, L-O
[1]
;
Laing, A. Plettenberg
[10]
;
Hall, C.
[10]
;
Heap, A.
[10]
;
Penrhyn-Lowe, S.
[10]
;
McCabe, V, C.
;
Ainsworth, S.
[1]
;
Silva, R. R.
[3, 13]
;
Dorrestein, P. C.
[3]
;
Richardson, M. K.
[6]
;
Gutierrez, J. M.
[12]
;
Calvete, J. J.
[14]
;
Harrison, R. A.
[1]
;
Vetter, I
[4, 15]
;
Undheim, E. A. B.
[4, 5, 16, 17]
;
Wuester, W.
[10]
;
Casewell, N. R.
[1]
Total Authors: 29
|
| Affiliation: Show less - | [1] Univ Liverpool Liverpool Sch Trop Med, Ctr Snakebite Res & Intervent, Liverpool L3 5QA, Merseyside - England
[2] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 - USA
[3] Univ Calif San Diego, Collaborat Mass Spectrometry Innovat Ctr, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 - USA
[4] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072 - Australia
[5] Univ Queensland, Ctr Adv Imaging, St Lucia, Qld 4072 - Australia
[6] Leiden Univ, Inst Biol, NL-2333 BE Leiden - Netherlands
[7] Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14853 - USA
[8] Swansea Univ, Coll Sci, Dept Biosci, Swansea SA2 8PP, W Glam - Wales
[9] Nottingham Trent Univ, Sch Sci & Technol, Nottingham NG11 8NS - England
[10] Bangor Univ, Sch Nat Sci, Mol Ecol & Fisheries Genet Lab, Bangor LL57 2UW, Gwynedd - Wales
[11] Univ Liverpool Liverpool Sch Trop Med, Res Comp Unit, Liverpool L3 5QA, Merseyside - England
[12] Univ Costa Rica, Fac Microbiol, Inst Clodomiro Picado, San Jose 11501 - Costa Rica
[13] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Mol Sci Dept, Nucleo Pesquisa Prod Nat & Sintet NPPNS, Ribeirao Preto - Brazil
[14] CSIC, Evolutionary & Translat Ven Lab, Valencia 46010 - Spain
[15] Univ Queensland, Sch Pharm, Woolloongabba, Qld 4102 - Australia
[16] Norwegian Univ Sci & Technol, Ctr Biodivers Dynam, Dept Biol, N-7491 Trondheim - Norway
[17] Univ Oslo, Ctr Ecol & Evolutionary Synth, Dept Biosci, N-0316 Oslo - Norway
Total Affiliations: 17
|
| Document type: | Journal article |
| Source: | Science; v. 371, n. 6527, p. 386+, JAN 22 2021. |
| Web of Science Citations: | 17 |
| Abstract | |
Convergent evolution provides insights into the selective drivers underlying evolutionary change. Snake venoms, with a direct genetic basis and clearly defined functional phenotype, provide a model system for exploring the repeated evolution of adaptations. While snakes use venom primarily for predation, and venom composition often reflects diet specificity, three lineages of cobras have independently evolved the ability to spit venom at adversaries. Using gene, protein, and functional analyses, we show that the three spitting lineages possess venoms characterized by an up-regulation of phospholipase A(2) (PLA(2)) toxins, which potentiate the action of preexisting venom cytotoxins to activate mammalian sensory neurons and cause enhanced pain. These repeated independent changes provide a fascinating example of convergent evolution across multiple phenotypic levels driven by selection for defense. (AU) | |
| FAPESP's process: | 19/05026-4 - Development of a computational platform extensible and modular for analysis of metabolomics and metagenomics experiments: Innovating with the discovery of new enzymatic activities and derived natural products of interest |
| Grantee: | Ricardo Roberto da Silva |
| Support Opportunities: | Scholarships in Brazil - BIOTA - Young Researchers |
| FAPESP's process: | 17/18922-2 - Development of a computing platform extensible and modular for metabolomics and metagenomics analysis: innovation with the discovery of new enzymatic activities and natural products of pharmaceutical interest derived |
| Grantee: | Ricardo Roberto da Silva |
| Support Opportunities: | BIOTA-FAPESP Program - Young Investigators Grants |