| Texto completo | |
| Autor(es): Mostrar menos - |
Pereira, Larissa M. N.
[1, 2, 3]
;
Assis, Patricia A.
[3]
;
de Araujo, Natalia M.
[1, 2]
;
Durso, Danielle F.
[3]
;
Junqueira, Caroline
[2]
;
Ataide, Marco Antonio
[1, 2]
;
Pereira, Dhelio B.
[4]
;
Lien, Egil
[3]
;
Fitzgerald, Katherine A.
[3]
;
Zamboni, Dario S.
[5]
;
Golenbock, Douglas T.
[2, 3]
;
Gazzinelli, Ricardo T.
[1, 2, 3, 6]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Fed Minas Gerais, Dept Bioquim & Imunol, ICB, BR-31270901 Belo Horizonte, MG - Brazil
[2] FIOCRUZ MG, Inst Rene Rachou, BR-30190002 Belo Horizonte, MG - Brazil
[3] Univ Massachusetts, Dept Med, Med Sch, Worcester, MA 01605 - USA
[4] FIOCRUZ RO, Ctr Pesquisas Med Trop, BR-76812329 Porto Velho, RO - Brazil
[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biol Celular Mol & Bioagentes Patogen, BR-14049900 Ribeirao Preto, SP - Brazil
[6] Fundacao Oswaldo Cruz, Fac Med Ribeirao Preto, Plataforma Med Translac, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURE COMMUNICATIONS; v. 11, n. 1 SEP 14 2020. |
| Citações Web of Science: | 3 |
| Resumo | |
Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Plasmodium chabaudi-infected mice and the P. berghei-induced experimental cerebral malaria (ECM). Importantly, our results indicate that the combined deficiencies of caspases-8/1/11 or caspase-8/gasdermin-D (GSDM-D) renders mice impaired to produce both TNF alpha and IL-1 beta and highly resistant to lethality in these models, disclosing a complementary, but independent role of caspase-8 and caspases-1/11/GSDM-D in the pathogenesis of malaria. Further, we find that monocytes from malaria patients express active caspases-1, -4 and -8 suggesting that these inflammatory caspases may also play a role in the pathogenesis of human disease. (AU) | |
| Processo FAPESP: | 16/23618-8 - Mecanismos imunológicos de resistência e patogênese da malária |
| Beneficiário: | João Santana da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |