In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis

Autor(es)

Alvarenga, Tavane Aparecida ^[1] ; Alvarenga Alves, Osvaine Junior ^[1] ; Pagotti, Mariana Cintra ^[1] ; Cunha, Wilson Roberto ^[2] ; Andrade e Silva, Marcio Luis ^[2] ; Sales, Juliana de Fatima ^[3] ; Silva, Fabiano Guimaraes ^[3] ; Januario, Ana Helena ^[2] ; Magalhaes, Lizandra Guidi ^[2] ; Paulettia, Patricia Mendonca ^[2]

Afiliação do(s) autor(es)

^[1] Univ Franca, Programa Posgrad Ciencias, BR-14404600 Franca, SP - Brazil

^[2] Univ Franca, BR-14404600 Franca, SP - Brazil

^[3] Inst Fed Educ Cienca & Tecnol Goiano, BR-75901970 Rio Verde, Go - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACTA BRASILIENSIS; v. 5, n. 1, p. 44-47, JAN-APR 2021.
• Citações Web of Science: 0

Resumo

This study analyzes the antileishmanial activity of the crude ethanol extract, fractions, and isolated compounds of A. othonianum nuts. Antileishmanial activity was evaluated against Leishmania amazonensis promastigotes in vitro. The phytochemical study was performed by high-performance liquid chromatography-high-resolution mass spectrometry-diode array detector (HPLC-HRMS-DAD) and by preparative HPLC. HPLC-HRMS-DAD analysis of the bioactive extract confirmed the presence of ten alkyl phenol derivatives that had previously been isolated from A. occidentale. Bioassay-guided isolation afforded cardanol triene, cardanol diene, cardanol monoene, cardol triene, anacardic acid triene, anacardic acid diene, and anacardic acid monoene. Cardol triene gave an IC50 of 80.66 mu M. The obtained data suggest that the evaluated extract, fractions, and cardol triene had moderate activity against L. amazonensis promastigotes. This is the first description of alkyl phenols in A. othonianum. (AU)

• Processo FAPESP: 16/10313-4 - Estudo fitoquímico e avaliação das atividades esquistossomicida, citotóxica e leishmanicida de plantas do cerrado
• Beneficiário: Patricia Mendonça Pauletti
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular
• Processo FAPESP: 17/24860-0 - Avaliação da toxicidade aguda in vivo do extrato etanólico das folhas de Stizophyllum perforatum e estudo químico associado à avaliação das atividades antiparasitária e citotóxica in vitro
• Beneficiário: Osvaine Junior Alvarenga Alves
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto