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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis

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Author(s):
Alvarenga, Tavane Aparecida [1] ; Alvarenga Alves, Osvaine Junior [1] ; Pagotti, Mariana Cintra [1] ; Cunha, Wilson Roberto [2] ; Andrade e Silva, Marcio Luis [2] ; Sales, Juliana de Fatima [3] ; Silva, Fabiano Guimaraes [3] ; Januario, Ana Helena [2] ; Magalhaes, Lizandra Guidi [2] ; Paulettia, Patricia Mendonca [2]
Total Authors: 10
Affiliation:
[1] Univ Franca, Programa Posgrad Ciencias, BR-14404600 Franca, SP - Brazil
[2] Univ Franca, BR-14404600 Franca, SP - Brazil
[3] Inst Fed Educ Cienca & Tecnol Goiano, BR-75901970 Rio Verde, Go - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ACTA BRASILIENSIS; v. 5, n. 1, p. 44-47, JAN-APR 2021.
Web of Science Citations: 0
Abstract

This study analyzes the antileishmanial activity of the crude ethanol extract, fractions, and isolated compounds of A. othonianum nuts. Antileishmanial activity was evaluated against Leishmania amazonensis promastigotes in vitro. The phytochemical study was performed by high-performance liquid chromatography-high-resolution mass spectrometry-diode array detector (HPLC-HRMS-DAD) and by preparative HPLC. HPLC-HRMS-DAD analysis of the bioactive extract confirmed the presence of ten alkyl phenol derivatives that had previously been isolated from A. occidentale. Bioassay-guided isolation afforded cardanol triene, cardanol diene, cardanol monoene, cardol triene, anacardic acid triene, anacardic acid diene, and anacardic acid monoene. Cardol triene gave an IC50 of 80.66 mu M. The obtained data suggest that the evaluated extract, fractions, and cardol triene had moderate activity against L. amazonensis promastigotes. This is the first description of alkyl phenols in A. othonianum. (AU)

FAPESP's process: 16/10313-4 - Phytochemistry study and evaluation of the schistosomicidal, cytotoxicity and leishmanicidal activities from cerrado plants
Grantee:Patricia Mendonça Pauletti
Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
FAPESP's process: 17/24860-0 - Acute toxicity evaluation of Stizophyllum perforatum leaves crude ethanol extract in vivo and chemical study associated with the evaluation of antiparasitic and cytotoxic activities in vitro
Grantee:Osvaine Junior Alvarenga Alves
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)