| Texto completo | |
| Autor(es): |
Cavalca, Lucia Bonci
[1, 2]
;
Lahive, Ciaran W.
[2]
;
Gijsbers, Fleur
[1]
;
Pavan, Fernando Rogerio
[3]
;
Scheffers, Dirk-Jan
[1]
;
Deuss, Peter J.
[2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, NL-9747 AG Groningen - Netherlands
[2] Univ Groningen, Dept Chem Engn ENTEG, Nijenborgh 4, NL-9747 AG Groningen - Netherlands
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecules; v. 26, n. 5 MAR 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
In order to replace the huge amounts of copper salts used in citrus orchards, alternatives have been sought in the form of organic compounds of natural origin with activity against the causative agent of citrus canker, the phytopathogen Xanthomonas citri subsp. Citri. We synthesized a series of 4-alkoxy-1,2-benzene diols (alkyl-BDOs) using 1,2,4-benzenetriol (BTO) as a starting material through a three-step synthesis route and evaluated their suitability as antibacterial compounds. Our results show that alkyl ethers derived from 1,2,4-benzenetriol have bactericidal activity against X. citri, disrupting the bacterial cell membrane within 15 min. Alkyl-BDOs were also shown to remain active against the bacteria while in solution, and presented low toxicity to (human) MRC-5 cells. Therefore, we have demonstrated that 1,2,4-benzenetriol-a molecule that can be obtained from agricultural residues-is an adequate precursor for the synthesis of new compounds with activity against X. citri. (AU) | |
| Processo FAPESP: | 17/50216-0 - Uso de rejeitos agrícolas para o combate de fitopatógenos: formas ambientalmente amigáveis para combater o Xanthomonas citri |
| Beneficiário: | Henrique Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |