Influence of physical-mechanical properties on SPF in sunscreen formulations on ex vivo and in vivo skin

Autor(es)

Infante, V. H. P. ^{[1, 2, 3, 4, 5]} ; Maia Campos, P. M. B. G. ^[1] ; Calixto, L. S. ^[1] ; Darvin, M. E. ^{[2, 3, 4, 5]} ; Kroeger, M. ^{[2, 3, 4, 5]} ; Schanzer, S. ^{[2, 3, 4, 5]} ; Lohan, S. B. ^{[2, 3, 4, 5]} ; Lademann, J. ^{[2, 3, 4, 5]} ; Meinke, M. C. ^{[2, 3, 4, 5]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Av Cafe S-N, BR-14040903 Sao Paulo, SP - Brazil

^[2] Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin - Germany

^[3] Free Univ Berlin, Charitepl 1, D-10117 Berlin - Germany

^[4] HumboldtUniv Berlin, Charitepl 1, D-10117 Berlin - Germany

^[5] Berlin Inst Hlth, Dept Dermatol Venereol & Allergol, Charitepl 1, D-10117 Berlin - Germany

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Pharmaceutics; v. 598, APR 1 2021.
• Citações Web of Science: 1

Resumo

The sun protection factor (SPF) is related to the selected UV filters. The objective of this study was to evaluate and compare the rheological behavior and texture profile of two sunscreen formulations and to correlate these data with the obtained SPF values. Two formulations (F1 and F2) were developed with the same type and amount of UV filters - whereby one of them also contained ethoxylated lanolin as additional film former (F2). Their rheological behavior, texture profile and in vitro and in vivo SPF were analyzed. The film-forming properties were evaluated by skin profilometry and diffuse reflectance spectroscopy. The structures of the formulations were examined by two-photon tomography combined with fluorescence lifetime imaging, and the penetration profile into the stratum corneum was investigated by tape stripping. The formulation with lanolin presented lower and constant values for physical-mechanical parameters, with a higher and better reproducible SPF. Both formulations did not penetrate the viable epidermis. In conclusion, formulations with better surface deposition on the skin surface can influence the film formation and, consequently, improve the SPF. These findings are important to improve the efficacy of sunscreen formulations and reduce the addition of UV filters. (AU)

• Processo FAPESP: 19/12452-0 - Microscopia e espectroscopia: técnicas não invasivas para avaliar a penetração e a formação de radicais livres de formulações cosméticas na pele
• Beneficiário: Victor Hugo Pacagnelli Infante
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 16/13705-0 - Pesquisa e desenvolvimento dos produtos cosméticos para o público masculino com óleos essenciais: caracterização da pele, eficácia clínica, perfil de consumo e influência da publicidade
• Beneficiário: Victor Hugo Pacagnelli Infante
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto