Histopathological findings and immunohistochemical expression of the stem cell markers CD44, ALDH1, Bmi-1, and Nanog in oral solitary fibrous tumors

Autor(es)

Setubal Destro Rodrigues, Maria Fernanda ^[1] ; Tobouti, Priscila Lie ^[2] ; Molon, Angela Cristina ^[1] ; Sedassari, Bruno Tavares ^[3] ; Nunes, Fabio Daumas ^[2] ; Pinto Junior, Decio dos Santos ^[2] ; Orsini Machado de Sousa, Suzana Cantanhede ^[2]

Afiliação do(s) autor(es)

^[1] Nove Julho Univ, Biophoton Appl Hlth Sci, Rua Vergueiro 235, BR-01525000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Dent, Sao Paulo - Brazil

^[3] Nove Julho Univ, Sch Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 131, n. 4, p. 444-451, APR 2021.
• Citações Web of Science: 0

Resumo

Objectives. The aim of this study was to evaluate the histomorphologic presentation and the expression of stem cell-related markers in a series of oral solitary fibrous tumors (SFTs). Study Design. Histopathological variables and the expression of the standard stem cell markers CD34 and CD99, used for SFT diagnosis, as well as STAT6 were evaluated in 13 oral SFTs. The expression of the cancer stem cell markers CD44, ALDH1, Bmi-1, and Nanog and the tumor suppressor gene p16(Ink4a) were also investigated. Results. The majority of oral SFTs were circumscribed and characterized by a proliferation of spindle cells arranged in a hyalinized stroma. Only 2 oral SFTs showed >4 mitoses/10 high-power fields. Hypercellularity as well as nuclear and cellular pleomorphism were classified as low and moderate in most of the oral SFTs. All oral SFTs were positive for CD34, STAT6, CD44, ALDH1, Bmi-1, and p16(Ink4a). CD99 and Nanog expression was observed in 11 and 10 oral SFT cases, respectively. Conclusion. We suggest that STAT6 and ALDH1 have relevant diagnostic value. The expression of CD44, ALDH1, Bmi-1, and Nanog, which is observed in cancer stem cells, may confer advantages to oral SFT cells. (AU)

• Processo FAPESP: 11/21395-8 - Análise funcional da participação de vias de sinalização em células-tronco tumorais isoladas de linhagens celulares derivadas de carcinoma epidermóide bucal.
• Beneficiário: Maria Fernanda Setúbal Destro Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/00786-1 - Análise funcional da participação de vias de sinalização em células-tronco tumorais isoladas de linhagens celulares derivadas de carcinoma epidermóide bucal
• Beneficiário: Fabio Daumas Nunes
• Modalidade de apoio: Auxílio à Pesquisa - Regular