Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus

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Gazeta, Rosa Estela ^[1] ; Bertozzi, Ana Paula Antunes Pascalicchio ^[1] ; Dezena, Rita de Cassia de Aguirre Bernardes ^[2] ; Silva, Andrea Cristina Botelho ^[3] ; Fajardo, Thamirys Cosmo Gillo ^[3] ; Catalan, Daniel T. ; Rizzo, Maria de Fatima Valente ^[1] ; Moron, Antonio Fernandes ^[4] ; Soriano-Arandes, Antoni ^[5] ; Clemente, Nuria Sanchez ^[6] ; Quintella, Tania ^[7] ; Ventura, Dora Fix ^[8] ; Damico, Francisco Max ^[8] ; Franca, Valtenice de Cassia Rodrigues de Matos ^[8] ; de Almeida, Juliana Paula Gomes ^[9] ; Zara, Ana Laura de Sene Amancio ^[10] ; Pires, Lucas Castro ^[11] ; Jundiai, Cohort Zika virus ^[12] ; Passos, Saulo Duarte ^[1]

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^[1] Jundiai Med Sch, Dept Pediat, BR-13202550 Jundiai - Brazil

^[2] Univ Ctr Campo Limpo Paulista UNIFACCAMP, BR-13231230 Sao Paulo - Brazil

^[3] Jundiai Med Sch, Pediat Infectol Lab, BR-13202550 Jundiai - Brazil

^[4] Univ Sao Paulo, Inst Trop Med, Campus Sao Paulo, BR-05403000 Sao Paulo - Brazil

^[5] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Vall dHebron Res Inst, Paediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035 - Spain

^[6] London Sch Hyg & Trop Med, Infect Dis Epidemiol, London WC1E 7HT - England

^[7] Pontificia Univ Catolica Campinas, Dept Pediat, Pediat Emergency Dept, BR-13086900 Campinas - Brazil

^[8] Univ Sao Paulo, Inst Psychol, Dept Expt Psychol, Campus Sao Paulo, BR-05588030 Sao Paulo - Brazil

^[9] Sch Med Sci Santa Casa Sao Paulo, Pediat Neurol Dept, BR-01221010 Sao Paulo - Brazil

^[10] Univ Fed Goias, Trop Inst & Publ Hlth, Dept Collect Hlth, BR-74690000 Goiania, Go - Brazil

^[11] Jundiai Med Sch, Fac Med, BR-13202 Jundiai - Brazil

^[12] Cohort Zika Virus Jundiai, BR-13207450 Jundiai - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Viruses-Basel; v. 13, n. 3 MAR 2021.
• Citações Web of Science: 0

Resumo

Congenital Zika virus (ZIKV) infection may present with a broad spectrum of clinical manifestations. Some sequelae, particularly neurodevelopmental problems, may have a later onset. We conducted a prospective cohort study of 799 high-risk pregnant women who were followed up until delivery. Eighty-three women and/or newborns were considered ZIKV exposed and/or infected. Laboratory diagnosis was made by polymerase chain reaction in the pregnant mothers and their respective newborns, as well as Dengue virus, Chikungunya virus, and ZIKV serology. Serology for toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, and syphilis infections were also performed in microcephalic newborns. The newborns included in the study were followed up until their third birthday. Developmental delay was observed in nine patients (13.2%): mild cognitive delay in three patients, speech delay in three patients, autism spectrum disorder in two patients, and severe neurological abnormalities in one microcephalic patient; sensorineural hearing loss, three patients and dysphagia, six patients. Microcephaly due to ZIKV occurred in three patients (3.6%). Clinical manifestations can appear after the first year of life in children infected/exposed to ZIKV, emphasizing the need for long-term follow-up. (AU)

• Processo FAPESP: 14/26818-2 - Desenvolvimento e implantação de métodos de avaliação visual: aplicações clínicas e em modelos animais
• Beneficiário: Dora Selma Fix Ventura
• Modalidade de apoio: Auxílio à Pesquisa - Temático