L-Glutamine Supplementation Enhances Strength and Power of Knee Muscles and Improves Glycemia Control and Plasma Redox Balance in Exercising Elderly Women

Autor(es):Mostrar menos -

Amirato, Gislene R. ^[1] ; Borges, Juliana O. ^[1] ; Marques, Daniella L. ^[1] ; Santos, Juliana M. B. ^[2] ; Santos, Carlos A. E. ^[3] ; Andrade, Marilia S. ^[4] ; Furtado, Guilherme E. ^[5] ; Rossi, Marcelo ^[6] ; Luis, Lais N. ^[1] ; Zambonatto, Raquel F. ^[1] ; da Silva, Eliane B. ^[1] ; Poma, Sarah O. ^[1] ; de Almeida, Mariana M. ^[1] ; Pelaquim, Renato L. ^[1] ; dos Santos-Oliveira, Laiane C. ^[1] ; Sousa Diniz, Vinicius L. ^[1] ; Passos, Maria E. P. ^[1] ; Levada-Pires, Adriana C. ^[1] ; Gorjao, Renata ^[1] ; Barros, Marcelo P. ^[1] ; Bachi, Andre L. L. ^{[6, 7]} ; Pithon-Curi, Tania C. ^[1]

Afiliação do(s) autor(es)

^[1] Cruzeiro do Sul Univ, Inst Phys Act Sci & Sports ICAFE, Interdisciplinary Postgrad Program Hlth Sci, BR-01506000 Sao Paulo, SP - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human & Rehabil, BR-11015020 Santos, SP - Brazil

^[3] Fed Univ Sao Paulo UNIFESP, Dept Med Geriatr & Gerontol, BR-04020050 Sao Paulo, SP - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Dept Physiol, BR-04023901 Sao Paulo, SP - Brazil

^[5] Nursing Sch Coimbra ESEnfC, Hlth Sci Res Unit Nursing UICISA E, P-3000232 Coimbra - Portugal

^[6] Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, BR-04829300 Sao Paulo, SP - Brazil

^[7] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, ENT Lab, BR-04023062 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRIENTS; v. 13, n. 3 MAR 2021.
• Citações Web of Science: 2

Resumo

We investigated the effects of oral L-glutamine (Gln) supplementation, associated or not with physical exercises, in control of glycemia, oxidative stress, and strength/power of knee muscles in elderly women. Physically active (n = 21) and sedentary (n = 23) elderly women aged 60 to 80 years were enrolled in the study. Plasma levels of D-fructosamine, insulin, reduced (GSH) and oxidized (GSSG) glutathione, iron, uric acid, and thiobarbituric acid-reactive substances (TBARs) (lipoperoxidation product), as well as knee extensor/flexor muscle torque peak and average power (isokinetic test), were assessed pre- and post-supplementation with Gln or placebo (30 days). Higher plasma D-fructosamine, insulin, and iron levels, and lower strength/power of knee muscles were found pre-supplementation in the NPE group than in the PE group. Post-supplementation, Gln subgroups showed higher levels of GSH, GSSG, and torque peak, besides lower D-fructosamine than pre-supplementation values. Higher muscle average power and plasma uric acid levels were reported in the PE + Gln group, whereas lower insulin levels were found in the NPE + Gln than pre-supplementation values. TBARs levels were diminished post-supplementation in all groups. Gln supplementation, mainly when associated with physical exercises, improves strength and power of knee muscles and glycemia control, besides boosting plasma antioxidant capacity of elderly women. (AU)

• Processo FAPESP: 19/14115-0 - Influência da suplementação de L-glutamina na sarcopenia e resposta imune/inflamatória sistêmica e das vias aéreas de idosos praticantes ou não de um programa regular de exercícios físicos combinados submetidas à vacinação contra o vírus Influenza
• Beneficiário: André Luis Lacerda Bachi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/06032-2 - Estratégias bioquímicas, fisiológicas e transcriptômicas para o estudo da relação entre carotenóides, estresse oxidativo e qualidade de frutas cítricas
• Beneficiário: Marcelo Paes de Barros
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 10/50025-1 - Influência da atividade física na resposta imune sistêmica e da mucosa das vias aéreas superiores de idosos submetidos a vacinação contra doenças respiratórias
• Beneficiário: André Luis Lacerda Bachi
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado