The protective effect of Artepillin C against lipid oxidation on model membranes

Autor(es)

Pazin, Wallance Moreira ^[1] ; Marques Ruiz, Gilia Cristine ^[1] ; dos Santos, Marcelo Jose ^[1] ; Benites Aoki, Pedro Henrique ^[2] ; Ito, Amando Siuiti ^[3] ; Leopoldo Constantino, Carlos Jose ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Technol & Appl Sci, BR-19060900 Presidente Prudente, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Sci Humanities & Languages, BR-19806900 Assis, SP - Brazil

^[3] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, BR-14040901 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MOLECULAR LIQUIDS; v. 324, FEB 15 2021.
• Citações Web of Science: 0

Resumo

Brazilian green propolis is awell-known therapeutic product, commonly used in folk medicine. Artepillin C is the major compound of Brazilian green propolis and has received considerable attention owing to its lipophilic affinity and antioxidant activity, enabling the use against lipid oxidation caused by free radicals, which is a first step before degenerative diseases. The protective effect of Artepillin C against lipid oxidation was evaluated here on models of lipid membranes based on Langmuir monolayers and giant unilamellar vesicles (GUVs) formed of 1,2-dioleoyl-sn-glycero-3-phosphocholine DOPC under oxidative stress induced by the photoactivated erythrosin. Our findings show that the lipophilic character of Artepillin C allows the donation of a hydrogen atom of the phenolic hydroxyl group to the lipid radical of both mono and bilayer, avoiding the formation of truncated aldehyde lipids, interrupting oxidative reactions mediated by reactive oxygen species (ROS), therefore playing a role as an antioxidant compound in the lipid environment. The affinity of Artepillin C for lipid structures, together with its antioxidant potential, preclude the lipid peroxidation caused by reactive species. (C) 2020 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 16/09633-4 - Mecanismo de ação do composto bioativo Artepillin C em sistemas miméticos de membranas e membranas citoplasmáticas de células tumorais
• Beneficiário: Wallance Moreira Pazin
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/22214-6 - Rumo à convergência de tecnologias: de sensores e biossensores à visualização de informação e aprendizado de máquina para análise de dados em diagnóstico clínico
• Beneficiário: Osvaldo Novais de Oliveira Junior
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/16713-0 - Terapia fotodinâmica: de efeitos moleculares em sistemas modelos a eficiência fotodinâmica em cultivo celular
• Beneficiário: Pedro Henrique Benites Aoki
• Modalidade de apoio: Auxílio à Pesquisa - Regular