Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration

Autor(es)

Moriscot, Anselmo ^[1] ; Miyabara, Elen H. ^[1] ; Langeani, Bruno ^[2] ; Belli, Antonio ^[3] ; Egginton, Stuart ^[4] ; Bowen, T. Scott ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil

^[2] Sou Paz Inst, Sao Paulo - Brazil

^[3] Univ Birmingham, NIHR Surg Reconstruct & Microbiol Res Ctr, Birmingham, W Midlands - England

^[4] Univ Leeds, Sch Biomed Sci, Fac Biol Sci, Leeds, W Yorkshire - England

• Tipo de documento: Artigo de Revisão
• Fonte: NPJ REGENERATIVE MEDICINE; v. 6, n. 1 MAR 26 2021.
• Citações Web of Science: 0

Resumo

One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma include soft-tissue damage and loss, haemorrhage, bone fracture, and pain. The majority of injuries are of musculoskeletal origin and located in the extremities, such that skeletal muscle offers a major therapeutic target to aid recovery and return to normal daily activities. However, the underlying pathophysiology of skeletal muscle ballistic trauma remains poorly understood, with limited evidence-based treatment options. As such, this review will address the topic of firearm-related skeletal muscle injury and regeneration. We first introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. Finally, we evaluate novel approaches for minimising muscle damage and enhancing muscle regeneration after ballistic trauma, which may have important relevance for primary care in victims of violence. (AU)

• Processo FAPESP: 18/50085-6 - BNRL Impact Gunshot Wounds Muscle Regeneration | São Paulo - SP
• Beneficiário: Anselmo Sigari Moriscot
• Modalidade de apoio: Auxílio Organização - Reunião Científica