| Texto completo | |
| Autor(es): |
Yariwake, Victor Yuji
[1]
;
Torres, Janaina Iannicelli
[1]
;
dos Santos, Amandda Rakell Peixoto
[2]
;
Freitas, Sarah Cristina Ferreira
[3]
;
De Angelis, Katia
[3]
;
Farhat, Sylvia Costa Lima
[1, 4]
;
Camara, Niels Olsen Saraiva
[5]
;
Veras, Mariana Matera
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Expt Air Pollut, Av Dr Arnaldo, 455 1st Floor, Room 1220, BR-01246903 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Div Nephrol, Dept Med, Lab Expt Cellular Immunol, Sao Paulo - Brazil
[3] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Childrens Inst Hosp Clin, Sch Med, Pediat Rheumatol Unit, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplant Immunol, Sao Paulo - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PARTICLE AND FIBRE TOXICOLOGY; v. 18, n. 1 MAR 25 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Background Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 mu g/m(3) of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. Results Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA. Conclusions This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE. (AU) | |
| Processo FAPESP: | 17/05264-7 - Metabolismo celular, microbiota e sistema imune: novos paradigmas na fisiopatologia das doenças renais |
| Beneficiário: | Niels Olsen Saraiva Câmara |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/05187-5 - Avaliação dos efeitos da exposição a poluição atmosférica sobre o desenvolvimento de lúpus eritematoso sistêmico em camundongos NZBWF1 |
| Beneficiário: | Victor Yuji Yariwake |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |