| Full text | |
| Author(s): |
Yariwake, Victor Yuji
[1]
;
Torres, Janaina Iannicelli
[1]
;
dos Santos, Amandda Rakell Peixoto
[2]
;
Freitas, Sarah Cristina Ferreira
[3]
;
De Angelis, Katia
[3]
;
Farhat, Sylvia Costa Lima
[1, 4]
;
Camara, Niels Olsen Saraiva
[5]
;
Veras, Mariana Matera
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Expt Air Pollut, Av Dr Arnaldo, 455 1st Floor, Room 1220, BR-01246903 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Div Nephrol, Dept Med, Lab Expt Cellular Immunol, Sao Paulo - Brazil
[3] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Childrens Inst Hosp Clin, Sch Med, Pediat Rheumatol Unit, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplant Immunol, Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | PARTICLE AND FIBRE TOXICOLOGY; v. 18, n. 1 MAR 25 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 mu g/m(3) of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. Results Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA. Conclusions This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE. (AU) | |
| FAPESP's process: | 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology |
| Grantee: | Niels Olsen Saraiva Câmara |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/05187-5 - Evaluation of effects of exposure to air pollution in the development of systemic lupus erythematosus in NZBWF1 mice |
| Grantee: | Victor Yuji Yariwake |
| Support Opportunities: | Scholarships in Brazil - Master |