Short Dietary Intervention with Olive Oil Increases Brown Adipose Tissue Activity in Lean but not Overweight Subjects

Autor(es):Mostrar menos -

Monfort-Pires, Milena ^[1] ; U-Din, Mueez ^[2] ; Nogueira, Guilherme A. ^[1] ; de Almeida-Faria, Juliana ^[1] ; Sidarta-Oliveira, Davi ^[1] ; Sant'Ana, Marcella Ramos ^[3] ; de Lima-Junior, Jose C. ^[1] ; Cintra, Dennys E. ^[3] ; de Souza, Heraldo Possolo ^[4] ; Ferreira, Sandra R. G. ^[5] ; Sapienza, Marcelo Tatit ^[6] ; Virtanen, Kirsi A. ^{[2, 7]} ; Velloso, Licio A. ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, BR-13084970 Sao Paulo, SP - Brazil

^[2] Turku Univ Hosp, Turku PET Ctr, Turku 20520 - Finland

^[3] Univ Estadual Campinas, Nutr Genom Lab, LabGeN, Sch Appl Sci, BR-13484350 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Med Sch, Dept Emergency Med, BR-05403000 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Dept Epidemiol, Sch Publ Hlth, BR-01246904 Sao Paulo, SP - Brazil

^[6] Univ Sao Paulo FMUSP, Dept Radiol & Oncol, Div Nucl Med, Med Sch, BR-05403911 Sao Paulo - Brazil

^[7] Univ Eastern Finland UEF, Inst Publ Hlth & Clin Nutr, Clin Nutr, Kuopio 70210 - Finland

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM; v. 106, n. 2, p. 472-484, FEB 2021.
• Citações Web of Science: 1

Resumo

Background: The brown adipose tissue (BAT) is a potential target for the treatment of obesity and metabolic disorders. Its activation by cold exposure or adrenergic drugs can increase systemic insulin sensitivity and improve lipid metabolism; however, little is known about the effects of specific dietary components on BAT activity. Objectives: We asked if a short-term (4 weeks) dietary intervention with olive oil could modify BAT activity in lean and overweight/obese volunteers. Design: This was a 4-week open clinical trial in which all participants underwent a dietary intervention with extra-virgin olive oil supplementation. As the initial intake of olive oil was controlled all the participants were controls of themselves. Results: The intervention resulted in significant increase in blood monounsaturated fatty acid levels, which was accompanied by increased BAT activity in lean but not in overweight/obese volunteers. In the lean group, an increase in leptin was detected after the intervention, and low leptin values at the beginning of the study were predictive of greater BAT activity after intervention. In addition, increase in leptin concentration was associated with increased BAT activity. Three known endogenous mediators of BAT activity, secretin, fibroblast growth factor 21 (FGF21), and 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) were increased by intervention in lean, whereas only secretin and FGF21 were increased in subjects with excessive weight. Conclusion: This study provides clinical evidence for the impact of monounsaturated fatty acids on BAT activity and an advance in the understanding of the beneficial health effects of olive oil. (AU)

• Processo FAPESP: 16/10616-7 - Efeito do consumo de ácidos graxos monoinsaturados na atividade do tecido adiposo marrom/bege de humanos adultos
• Beneficiário: Milena Monfort Pires
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/02055-3 - Taxa de absorção de glicose avaliada por PET/RM dinâmico como método para determinação de tecido adiposo marrom em humanos - Potencial associação com atividade cerebral
• Beneficiário: Milena Monfort Pires
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 18/05479-6 - Treinamento para determinação de tecido adiposo marrom de humanos utilizando imagens de PET/RM
• Beneficiário: Milena Monfort Pires
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado