A5 noradrenergic neurons and breathing control in neonate rats

Autor(es)

Taxini, Camila L. ^[1] ; Marques, Danuzia A. ^[2] ; Bicego, Kenia C. ^[1] ; Gargaglioni, Luciane H. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, FCAV, Dept Morphol & Anim Physiol, Via Acesso Paulo Donato Castellane S-N, BR-14870900 Jaboticabal, SP - Brazil

^[2] Univ Laval, Univ Cardiol & Pneumol Quebec, Ctr Rech Inst, Dept Pediat, Quebec City, PQ G1V 4G5 - Canada

• Tipo de documento: Artigo Científico
• Fonte: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY; v. 473, n. 6 APR 2021.
• Citações Web of Science: 0

Resumo

The pontine A5 noradrenergic group contributes to the maturation of the respiratory system before birth in rats. These neurons are connected to the neural network responsible for respiratory rhythmogenesis. In the present study, we investigated the participation of A5 noradrenergic neurons in neonates (P7-8 and P14-15) in the control of ventilation during hypoxia and hypercapnia in in vivo experiments using conjugated saporin anti-dopamine beta-hydroxylase (D beta H-SAP) to specifically ablate noradrenergic neurons. Thus, D beta H-SAP (420 ng/mu L) or saporin (SAP, control) was injected into the A5 region of neonatal male Wistar rats. Hypoxia reduced respiratory variability in control animals; however, A5 lesion prevented this effect in P7-8 rats. Our data suggest that noradrenergic neurons of the A5 region in neonate rats do not participate in the control of ventilation under baseline and hypercapnic conditions, but exert an inhibitory modulation on breathing variability under hypoxic challenge in early life (P7-8). (AU)

• Processo FAPESP: 19/09469-8 - Efeito da temperatura de incubação no metabolismo, termorregulação e quimiossensibilidade de frangos
• Beneficiário: Luciane Helena Gargaglioni Batalhão
• Modalidade de apoio: Auxílio à Pesquisa - Regular