The role of CD68+and CD163+macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions

Autor(es)

Ferrisse, Tulio Morandin ^[1] ; de Oliveira, Analu Barros ^[2] ; Palacon, Mariana Paravani ^[1] ; Silva, Evanio Vilela ^[1] ; Sgavioli Massucato, Elaine Maria ^[1] ; de Almeida, Luciana Yamamoto ^[3] ; Leon, Jorge Esquiche ^[4] ; Bufalino, Andreia ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Sch Dent, Dept Diag & Surg, Oral Med, UNESP, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ, Sch Dent, Dept Orthodont & Pediat Dent, UNESP, Araraquara, SP - Brazil

^[3] Univ Sao Paulo, Dept Pathol & Forens Med, Ribeirao Preto Med Scholl FMRP USP, Ribeirao Preto - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Dent Sch FORP USP, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ave Cafe S-N, BR-14040904 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Immunobiology; v. 226, n. 3 MAY 2021.
• Citações Web of Science: 0

Resumo

Macrophages are phagocytic cells with essential participation in immunological events of the oral cavity. However, the role of these cells in oral lichen planus (OLP) and oral lichenoid lesions (OLL) remains unclear. The present study aimed to evaluate the density of macrophages in OLP and OLL, and to compare it with that of oral inflammatory fibrous hyperplasia (OIFH) (control group). 14 cases of OLP, 14 cases of OLL and 14 cases of OIFH were selected for immunohistochemical analysis of CD68(+) (M1) and CD163(+) (M2) macrophage expression. CD68(+) and CD163(+) macrophages densities were measured in the intraepithelial and subepithelial areas. The statistical tests used were multivariate analysis of variance, as well as a correlation and linear regression. OLP has more CD68(+) macrophages when comparing with OLL (p = 0.001) and OIFH (p = 0.045). There is a very strong relationship between the macrophages types (p < 0.0001) in OLP and OLL. The linear regression showed that to OLL development (p < 0.0001/R-2' = 0.9584), the presence of different types of macrophages are more essential than to OLP (p < 0.0001/R-2' = 0.8983). However, in the OLP these dependencies are also largely. CD68(+) macrophages may be associated with immunopathogenesis of OLP, indicating a pro-inflammatory activity and regulatory role in the type of T-cell response. Besides, CD68(+) macrophages can cooperate in the diagnosis of OLP. These results are essential to future studies that seek a therapeutic target for OLP and OLL. (AU)

• Processo FAPESP: 20/07110-0 - Potencial da terapia fotodinâmica na modulação da resposta inflamatória e nos fatores de virulência microbianos: avaliação em modelo de co-culturas tridimensionais de fibroblastos gengivais, Candida albicans e Staphylococcus aureus
• Beneficiário: Analú Barros de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/11419-0 - Correlação clinicopatológica do grau de diferenciação, expressão de tetraspaninas, agentes virais e proliferação celular em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço.
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/01438-0 - Análise do papel da resposta imune inata e adaptativa na leucoplasia oral e leucoplasia verrucosa proliferativa
• Beneficiário: Andreia Bufalino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/18440-0 - Bioprospecção de produtos naturais em terapia fotodinâmica contra micro-organismos de interesse médico-odontológico
• Beneficiário: Analú Barros de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado