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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of CD68+and CD163+macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions

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Ferrisse, Tulio Morandin [1] ; de Oliveira, Analu Barros [2] ; Palacon, Mariana Paravani [1] ; Silva, Evanio Vilela [1] ; Sgavioli Massucato, Elaine Maria [1] ; de Almeida, Luciana Yamamoto [3] ; Leon, Jorge Esquiche [4] ; Bufalino, Andreia [1]
Total Authors: 8
[1] Sao Paulo State Univ, Sch Dent, Dept Diag & Surg, Oral Med, UNESP, Araraquara, SP - Brazil
[2] Sao Paulo State Univ, Sch Dent, Dept Orthodont & Pediat Dent, UNESP, Araraquara, SP - Brazil
[3] Univ Sao Paulo, Dept Pathol & Forens Med, Ribeirao Preto Med Scholl FMRP USP, Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Dent Sch FORP USP, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ave Cafe S-N, BR-14040904 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Immunobiology; v. 226, n. 3 MAY 2021.
Web of Science Citations: 0

Macrophages are phagocytic cells with essential participation in immunological events of the oral cavity. However, the role of these cells in oral lichen planus (OLP) and oral lichenoid lesions (OLL) remains unclear. The present study aimed to evaluate the density of macrophages in OLP and OLL, and to compare it with that of oral inflammatory fibrous hyperplasia (OIFH) (control group). 14 cases of OLP, 14 cases of OLL and 14 cases of OIFH were selected for immunohistochemical analysis of CD68(+) (M1) and CD163(+) (M2) macrophage expression. CD68(+) and CD163(+) macrophages densities were measured in the intraepithelial and subepithelial areas. The statistical tests used were multivariate analysis of variance, as well as a correlation and linear regression. OLP has more CD68(+) macrophages when comparing with OLL (p = 0.001) and OIFH (p = 0.045). There is a very strong relationship between the macrophages types (p < 0.0001) in OLP and OLL. The linear regression showed that to OLL development (p < 0.0001/R-2' = 0.9584), the presence of different types of macrophages are more essential than to OLP (p < 0.0001/R-2' = 0.8983). However, in the OLP these dependencies are also largely. CD68(+) macrophages may be associated with immunopathogenesis of OLP, indicating a pro-inflammatory activity and regulatory role in the type of T-cell response. Besides, CD68(+) macrophages can cooperate in the diagnosis of OLP. These results are essential to future studies that seek a therapeutic target for OLP and OLL. (AU)

FAPESP's process: 20/07110-0 - Potential of photodynamic therapy in modulating the inflammatory response and microbial virulence factors: evaluation in a model of three-dimensional co-cultures of gingival fibroblasts, Candida albicans and Staphylococcus aureus
Grantee:Analú Barros de Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
Grantee:Jorge Esquiche León
Support type: Regular Research Grants
FAPESP's process: 17/01438-0 - The role of the innate and adaptive immune responses in oral leukoplakia and oral proliferative verrucous leukoplakia
Grantee:Andreia Bufalino
Support type: Regular Research Grants
FAPESP's process: 18/18440-0 - Bioprospection of natural products in photodynamic therapy against microorganisms of medial and dental importance
Grantee:Analú Barros de Oliveira
Support type: Scholarships in Brazil - Master