Mycotoxin occurrence in breast milk and exposure estimation of lactating mothers using urinary biomarkers in Sao Paulo, Brazil

Autor(es):Mostrar menos -

Coppa, Carolina F. S. C. ^[1] ; Cirelli, Amanda C. ^[1] ; Goncalves, Bruna L. ^[1] ; Barnabe, Eliana M. B. ^[2] ; Petta, Tania ^[3] ; Franco, Larissa T. ^[1] ; Javanmardi, Fardin ^[4] ; Khaneghah, Amin Mousavi ^[5] ; Lee, I, Sarah H. ; Corassin, Carlos H. ^[6] ; Oliveira, Carlos A. F. ^[6]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Anim Sci & Food Engn, Dept Food Engn, Av Duque Caxias Norte, BR-13635900 Pirassununga, SP - Brazil

^[2] Pirassununga Med Special Ctr, Maternal & Child Unit, Antonio Joaquim Mendes 1017, BR-13634502 Pirassununga, SP - Brazil

^[3] Supera Parque Inovacao & Tecnol Ribeirao Preto, Actinobac Agrosci, Av Dra Nadir Aguiar, BR-14056680 Ribeirao Preto, SP - Brazil

^[4] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Dept Food Sci & Technol, Natl Nutr & Food Technol Res Inst, Tehran - Iran

^[5] Univ Estadual Campinas, Fac Food Engn, Dept Food Sci, UNICAMP, Campinas, SP - Brazil

^[6] Lee, Sarah H., I, Univ Sao Paulo, Sch Anim Sci & Food Engn, Dept Food Engn, Av Duque Caxias Norte, BR-13635900 Pirassununga, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Environmental Pollution; v. 279, JUN 15 2021.
• Citações Web of Science: 4

Resumo

In this study, the occurrence of aflatoxins (AFs), fumonisins (FBs), ochratoxin A (OTA), deoxynivalenol (DON), zearalenone (ZEN) and some of their metabolites were assessed in breast milk and urine of lactating women (N = 74) from Pirassununga, Sao Paulo, Brazil. Exposure estimations through urinary mycotoxin biomarkers was also performed. Samples were collected in four sampling times (May and August 2018, February and July 2019) and analyzed by liquid chromatography coupled to tandem mass spectrometry. Aflatoxin M1 (AFM1) was not detected in breast milk. However, two samples (3%) pre-sented FB1 at 2200 and 3400 ng/L, while 4 samples (5%) had OTA at the median level of 360 ng/L. In urine, AFM(1) and aflatoxin P-1 (AFP1) were found in 51 and 11% of samples, respectively (median levels: 0.16 and 0.07 ng/mg creatinine, respectively). Urinary DON (median level: 38.59 ng/mg creatinine), OTA (median level: 2.38 ng/mg creatinine) and ZEN (median level: 0.02 ng/mg of creatinine) were quantified in 18, 8 and 10% of the samples, respectively. Mean probable daily intake (PDI) values based on urinary biomarkers were 1.58, 1.09, 5.07, and 0.05 mu g/kg body weight/day for AFM(1), DON, OTA, and ZEN, respectively. Although a low mycotoxin occurrence was detected in breast milk, the PDI for the genotoxic AFs was much higher than those reported previously in Brazil, while PDI values obtained for OTA and DON were higher than recommended tolerable daily intakes. These outcomes warrant concern on the exposure of lactating women to these mycotoxins in the studied area. (C) 2021 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 19/21603-1 - Abordagens de biomarcadores para avaliar a exposição precoce a múltiplas micotoxinas na dieta
• Beneficiário: Carlos Augusto Fernandes de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/12956-2 - Avaliação de biomarcadores de exposição as micotoxinas em lactantes na região de Ribeirão Preto/SP
• Beneficiário: Carolina Fernanda Sengling Cebin Coppa
• Modalidade de apoio: Bolsas no Brasil - Doutorado