Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice

Autor(es):Mostrar menos -

Barssotti, Leticia ^[1] ; Abreu, Isabel C. M. E. ^[2] ; Brandao, Ana Beatriz P. ^[2] ; Albuquerque, Raquel C. M. F. ^[2] ; Ferreira, Fabiana G. ^[1] ; Salgado, Miguel A. C. ^[3] ; Dias, Danielle D. S. ^[4] ; De Angelis, Katia ^[4] ; Yokota, Rodrigo ^[2] ; Casarini, Dulce E. ^[2] ; Souza, Livia B. ^[2] ; Taddei, Carla R. ^[5] ; Cunha, Tatiana S. ^{[1, 6]}

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo Unifesp, Dept Sci & Technol, Sao Jose Dos Campos - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Dept Med, Sao Paulo - Brazil

^[3] State Univ Julio de Mesquita Filho Unesp, Dept Biosci & Oral Diag, Sao Jose Dos Campos - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Dept Clin & Toxicol Anal, Sao Paulo - Brazil

^[6] Fed Univ Sao Paulo Unifesp, Inst Sci & Technol, Talim 330 Vila Nair, BR-12231280 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 11, n. 1 APR 28 2021.
• Citações Web of Science: 1

Resumo

Type 1 diabetes (T1DM) is a chronic disease characterized by hyperglycemia due to a deficiency in endogenous insulin production, resulting from pancreatic beta cell death. Persistent hyperglycemia leads to enhanced oxidative stress and liver injury. Several studies have evaluated the anti-diabetic and protective effects of probiotic strains in animal models. In the present study, we investigated, through histopathological and biochemical analyses, the effects of eight weeks of administration of Saccharomyces boulardii (S. boulardii) yeast on the liver of streptozotocin (STZ) induced diabetic C57BL/6 mice. Our results demonstrated that S. boulardii attenuates hepatocytes hydropic degeneration and hepatic vessels congestion in STZ-induced diabetic mice. The treatment attenuated the oxidative stress in diabetic mice leading to a reduction of carbonylated protein concentration and increased activity of antioxidant enzymes superoxide dismutase and glutathione peroxidase, compared to untreated diabetic animals. The results also show the beneficial influence of S. boulardii in regulating the hepatic concentration of renin angiotensin system (RAS) peptides. Therefore, our results demonstrated that S. boulardii administration to STZ-induced diabetic mice reduces oxidative stress and normalizes the concentration of RAS peptides, supporting the hypothesis that this yeast may have a role as a potential adjunctive therapy to attenuate diabetes-induced liver injury. (AU)

• Processo FAPESP: 16/24059-2 - Efeito da administração do probiótico Saccharomyces boulardii na peroxidação lipídica de hepatócitos de camundongos diabéticos
• Beneficiário: Leticia Barssotti dos Santos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica