CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria

Autor(es):Mostrar menos -

Jones, Martin R. ^[1] ; Pinto, Ernani ^[2] ; Torres, Mariana A. ^[3] ; Dorr, Fabiane ^[3] ; Mazur-Marzec, Hanna ^[4] ; Szubert, Karolina ^[4] ; Tartaglione, Luciana ^[5] ; Dell'Aversano, Carmela ^[5] ; Miles, Christopher O. ^[6] ; Beach, Daniel G. ^[6] ; McCarron, Pearse ^[6] ; Sivonen, Kaarina ^[7] ; Fewer, David P. ^[7] ; Jokela, Jouni ^[7] ; Janssen, Elisabeth M-L ^[1]

Afiliação do(s) autor(es)

^[1] Swiss Fed Inst Aquat Sci & Technol Eawag, Dept Environm Chem, CH-8600 Dubendorf - Switzerland

^[2] Univ Sao Paulo, Ctr Nucl Energy Agr, BR-13418260 Piracicaba, SP - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci, BR-05508900 Sao Paulo, SP - Brazil

^[4] Univ Gdansk, Div Marine Biotechnol, Al Marszalka Pilsudskiego 46, PL-81378 Gdynia - Poland

^[5] Univ Napoli Federico II, Sch Med & Surg, Dept Pharm, Via D Montesano 49, I-80131 Naples - Italy

^[6] Natl Res Council Canada, Biotoxin Metrol, 1411 Oxford St, Halifax, NS B3H 3Z1 - Canada

^[7] Univ Helsinki, Dept Microbiol, Helsinki 00014 - Finland

• Tipo de documento: Artigo Científico
• Fonte: WATER RESEARCH; v. 196, MAY 15 2021.
• Citações Web of Science: 23

Resumo

Harmful cyanobacterial blooms, which frequently contain toxic secondary metabolites, are reported in aquatic environments around the world. More than two thousand cyanobacterial secondary metabolites have been reported from diverse sources over the past fifty years. A comprehensive, publically-accessible database detailing these secondary metabolites would facilitate research into their occurrence, functions and toxicological risks. To address this need we created CyanoMetDB, a highly curated, flat-file, openly-accessible database of cyanobacterial secondary metabolites collated from 850 peer-reviewed articles published between 1967 and 2020. CyanoMetDB contains 2010 cyanobacterial metabolites and 99 structurally related compounds. This has nearly doubled the number of entries with complete literature metadata and structural composition information compared to previously available open access databases. The dataset includes microcytsins, cyanopeptolins, other depsipeptides, anabaenopeptins, microginins, aeruginosins, cyclamides, cryptophycins, saxitoxins, spumigins, microviridins, and anatoxins among other metabolite classes. A comprehensive database dedicated to cyanobacterial secondary metabolites facilitates: (1) the detection and dereplication of known cyanobacterial toxins and secondary metabolites; (2) the identification of novel natural products from cyanobacteria; (3) research on biosynthesis of cyanobacterial secondary metabolites, including substructure searches; and (4) the investigation of their abundance, persistence, and toxicity in natural environments. Crown Copyright ? 2021 Published by Elsevier Ltd. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ) (AU)

• Processo FAPESP: 14/50420-9 - Metabólitos secundários produzidos por micro-organismos aquáticos e impacto na qualidade de frutos do mar e de peixes de água doce
• Beneficiário: Ernani Pinto Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular