Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients

Autor(es)

Canedo Silva, Maryanne Zilli ^[1] ; Antonio, Karina Jesus ^[1] ; Soares Reis, Joao Marcos ^[2] ; Alves, Leticia Salmazzo ^[2] ; Teixeira Caramori, Jacqueline Costa ^[1] ; Vogt, Barbara Perez ^[3]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP - Brazil

^[2] Univ Western Sao Paulo UNOESTE, Hlth Sci Sch, Nutr Course, Presidente Prudente - Brazil

^[3] Fed Univ Uberlandia UFU, Fac Med, Grad Program Hlth Sci, Uberlandia, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: KIDNEY RESEARCH AND CLINICAL PRACTICE; v. 40, n. 2, p. 294-303, JUN 2021.
• Citações Web of Science: 0

Resumo

Background: Due to the poor outcomes associated with the impairment of physical function and muscle strength in patients on maintenance dialysis, it is important to understand the factors that may influence physical function and muscle strength. The aim of this study was to explore the factors associated with physical function in hemodialysis and peritoneal dialysis patients. Methods: Patients with chronic kidney disease on dialysis for at least 3 months, aged 18 years old or above, were enrolled. Physical function was assessed by handgrip strength, gait and sit-to-stand tests, and the Short Physical Performance Battery (SPPB). Clinical and laboratory data were collected to verify the association with physical function parameters through binary logistic regression. Results: One-hundred ninety patients on maintenance dialysis were included; 140 patients (73.7%) on hemodialysis and 50 (26.3%) on peritoneal dialysis. The mean age was 57.3 +/- 14.9 years, 109 (57.4%) were male, and 87 (45.8%) were older than 60 years. The median SPPB was 8.0 points (6.0-10.0 points) and the mean +/- standard deviation of handgrip strength was 24.7 +/- 12.2 kg. Binary logistic regression showed that age, type of renal replacement therapy, diabetes mellitus, and serum creatinine were significantly associated with both higher 4-meter gait test times and lower SPPB scores. Only age and diabetes mellitus were associated with higher sit-to-stand test times, while age and ferritin were associated with lower handgrip strength. Conclusion: Age, diabetes mellitus, serum creatinine, and hemodialysis modality are factors related to physical function in dialysis patients. (AU)

• Processo FAPESP: 17/13187-2 - Associação do estado nutricional com função muscular, capacidade funcional e qualidade de vida em pacientes em hemodiálise crônica
• Beneficiário: João Marcos Soares Reis
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica