Contextualizing Autophagy during Gametogenesis and Preimplantation Embryonic Development

Autor(es)

Moura, Marcelo T. ^[1] ; Latorraca, Lais B. ^[1] ; Paula-Lopes, Fabiola E. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, UNIFESP, Dept Biol Sci, Campus Diadema, BR-09972270 Diadema, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 12 JUN 2021.
• Citações Web of Science: 0

Resumo

Mammals face environmental stressors throughout their lifespan, which may jeopardize cellular homeostasis. Hence, these organisms have acquired mechanisms to cope with stressors by sensing, repairing the damage, and reallocating resources to increase the odds of long-term survival. Autophagy is a pro-survival lysosome-mediated cytoplasm degradation pathway for organelle and macromolecule recycling. Furthermore, autophagy efflux increases, and this pathway becomes idiosyncratic depending upon developmental and environmental contexts. Mammalian germ cells and preimplantation embryos are attractive models for dissecting autophagy due to their metastable phenotypes during differentiation and exposure to varying environmental cues. The aim of this review is to explore autophagy during mammalian gametogenesis, fertilization and preimplantation embryonic development by contemplating its physiological role during development, under key stressors, and within the scope of assisted reproduction technologies. (AU)

• Processo FAPESP: 17/20125-3 - Alterações do perfil epigenético imediato e transgeracional causadas pelo estresse térmico no gameta feminino
• Beneficiário: Fabíola Freitas de Paula Lopes
• Modalidade de apoio: Auxílio à Pesquisa - Programa de Pesquisa sobre Mudanças Climáticas Globais - Regular
• Processo FAPESP: 17/13082-6 - Respostas oocitárias ao estresse térmico
• Beneficiário: Lais Barbosa Latorraca
• Modalidade de apoio: Bolsas no Brasil - Mestrado