Genome-wide scan reveals genomic regions and candidate genes underlying direct and maternal effects of preweaning calf mortality in Nellore cattle

Autor(es):Mostrar menos -

Marin-Garzon, N. A. ^[1] ; Magalhaes, A. F. B. ^[1] ; Schmidt, P. I. ^[1] ; Serna, M. ^[1] ; Fonseca, L. F. S. ^[1] ; Salatta, B. M. ^[1] ; Frezarim, G. B. ^[1] ; Fernandes-Junior, G. A. ^[1] ; Bresolin, T. ^[1] ; Carvalheiro, R. ^[1] ; Albuquerque, L. G. ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Coll Agr & Veterinarian Sci, Via Acesso Prof Paulo Donato Castelane Castellane, BR-14884900 Jaboticabal, SP - Brazil

^[2] Natl Council Sci & Technol Dev CNPq, Brasilia, DF - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Genomics; v. 113, n. 3, p. 1386-1395, MAY 2021.
• Citações Web of Science: 0

Resumo

We conducted analysis to estimate genetic parameters and to identify genomic regions and candidate genes affecting direct and maternal effects of preweaning calf mortality (PWM) in Nellore cattle. Phenotypic records of 67,196 animals, and 8443 genotypes for 410,936 SNPs were used. Analysis were performed through the weighted single-step GBLUP approach and considering a threshold animal model via Bayesian Inference. Direct and maternal heritability estimates were of 0.2143 +/- 0.0348 and 0.0137 +/- 0.0066, respectively. The top 10 genomic regions accounted for 13.61 and 14.23% of the direct and maternal additive genetic variances and harbored a total of 63 and 91 positional candidate genes, respectively. Two overlapping regions on BTA2 were identified for both direct and maternal effects. Candidate genes are involved in biological mechanisms i.e. embryogenesis, immune response, feto-maternal communication, circadian rhythm, hormone alterations, myometrium adaptation, and milk secretion, which are critical for the successful calf growth and survival during preweaning period. (AU)

• Processo FAPESP: 17/10630-2 - Aspectos genéticos da qualidade, eficiência e sustentabilidade da produção de carne em animais da raça Nelore
• Beneficiário: Lucia Galvão de Albuquerque
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/20026-8 - EMU concedido no processo 2017/10630-2: servidor
• Beneficiário: Lucia Galvão de Albuquerque
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários