Opsins outside the eye and the skin: a more complex scenario than originally thought for a classical light sensor

Autor(es)

Moraes, Maria Nathalia ^[1] ; de Assis, Leonardo Vinicius Monteiro ^[2] ; Provencio, Ignacio ^{[3, 4]} ; Castrucci, Ana Maria de Lauro ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Ave Prof Lineu Prestes 1524, BR-05508900 Sao Paulo - Brazil

^[2] Univ Lubeck, Inst Neurobiol, Lubeck - Germany

^[3] Univ Virginia, Dept Biol, Charlottesville, VA - USA

^[4] Univ Virginia, Dept Ophthalmol, Charlottesville, VA - USA

^[5] Univ Sao Paulo, Inst Biosci, Dept Physiol, Trav 14, 101, BR-05508090 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Cell and Tissue Research; v. 385, n. 3 JUL 2021.
• Citações Web of Science: 1

Resumo

Since the discovery of melanopsin as a retinal non-visual photopigment, opsins have been described in several organs and cells. This distribution is strikingly different from the classical localization of photopigments in light-exposed tissues such as the eyes and the skin. More than 10 years ago, a new paradigm in the field was created as opsins were shown, to detect not only light, but also thermal energy in Drosophila. In agreement with these findings, thermal detection by opsins was also reported in mammalian cells. Considering the presence of opsins in tissues not reached by light, an intriguing question has emerged: What is the role of a classical light-sensor, and more recently appreciated thermo-sensor, in these tissues? To tackle this question, we address in this review the most recent studies in the field, with emphasis in mammals. We provide the present view about the role of opsins in peripheral tissues, aiming to integrate the current knowledge of the presence and function of opsins in organs that are not directly affected by light. (AU)

• Processo FAPESP: 17/26651-9 - Glaucoma como modelo de ruptura da informação temporal: impacto sobre o metabolismo
• Beneficiário: Maria Nathália de Carvalho Magalhães Moraes Figueira Borges
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 17/24615-5 - Derrubando um paradigma? Melanopsina, um fotopigmento canônico, atuando como sensor para ajuste do relógio em órgãos não expostos à luz, e sua possível interação com canais TRP: estudo transdisciplinar envolvendo aspectos fisiológicos e patológicos
• Beneficiário: Ana Maria de Lauro Castrucci
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/14728-0 - Melanopsina como fotorreceptor de UVA e sua relação com pigmentação, reparo de DNA, relógio biológico e componentes do eixo HPA: um novo alvo farmacológico?
• Beneficiário: Ana Maria de Lauro Castrucci
• Modalidade de apoio: Auxílio à Pesquisa - Regular