Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation

Autor(es)

de Almeida-Filho, Daniel Gomes ^{[1, 2]} ; Koike, Bruna Del Vechio ^{[1, 3, 4]} ; Billwiller, Francesca ^{[1, 3]} ; Farias, Kelly Soares ^{[1, 3, 5]} ; Praxedes de Sales, Igor Rafael ^[1] ; Luppi, Pierre-Herve ^[3] ; Ribeiro, Sidarta ^[1] ; Queiroz, Claudio Marcos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Rio Grande do Norte, Brain Inst, Natal, RN - Brazil

^[2] Univ Calif Los Angeles, Integrat Ctr Learning & Memory, Brain Res Inst, Dept Neurobiol, Los Angeles, CA 90095 - USA

^[3] Univ Claude Bernard Lyon 1, UMR 5292, U1028, INSERM, CNRS, RTH Laennec, Fac Med, Ctr Res Neurosci Lyon, SLEEP T, Lyon - France

^[4] Fed Univ Sao Francisco Valley, Petrolina, PE - Brazil

^[5] State Univ Paraiba, Campina Grande, Paraiba - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 11, n. 1 JUN 22 2021.
• Citações Web of Science: 0

Resumo

Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon. (AU)

• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs