Low and High Frequency Vibration Perception Thresholds Can Improve the Diagnosis of Diabetic Neuropathy

Autor(es)

Drechsel, Tina J. ^[1] ; Monteiro, Renan L. ^[2] ; Zippenfennig, Claudio ^[1] ; Ferreira, Jane S. S. P. ^[2] ; Milani, Thomas L. ^[1] ; Sacco, Isabel C. N. ^[2]

Afiliação do(s) autor(es)

^[1] Tech Univ Chemnitz, Inst Human Movement Sci & Hlth, Fac Behav & Social Sci, Dept Human Locomot, D-09107 Chemnitz - Germany

^[2] Univ Sao Paulo, Fac Med, Dept Phys Therapy Speech & Occupat Therapy, BR-05360160 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL MEDICINE; v. 10, n. 14 JUL 2021.
• Citações Web of Science: 0

Resumo

Recent studies demonstrate neuropathic changes with respect to vibration sensitivity for different measurement frequencies. This study investigates the relationship between vibration perception thresholds (VPTs) at low and high frequencies at two plantar locations and diabetic peripheral neuropathy (DPN) severity in diabetes mellitus (DM) subjects with DPN. We examine differences of VPTs between participants with DM, with DPN, as well as healthy controls. The influence of anthropometric, demographic parameters, and DM duration on VPTs is studied. Thirty-three healthy control group subjects (CG: 56.3 +/- 9.9 years) and 33 with DM are studied. DM participants are subdivided into DM group (DM without DPN, n = 20, 53.3 +/- 15.1 years), and DPN group (DM with DPN, n = 13, 61.0 +/- 14.5 years). VPTs are measured at the first metatarsal head (MTH1) and heel (30 Hz, 200 Hz), using a customized vibration exciter. Spearman and Pearson correlations are used to identify relationships between VPTs and clinical parameters. ANOVAs are calculated to compare VPTs among groups. Significant correlations are observed between DPN severity (by fuzzy scores) and VPTs at both locations and frequencies (MTH1\_30 Hz vs. fuzzy: r = 0.68, p = 0.011; Heel\_30 Hz vs. fuzzy: r = 0.66, p = 0.014; MTH1\_200 Hz vs. fuzzy: r = 0.73, p = 0.005; Heel\_200 Hz vs. fuzzy: r = 0.60, p = 0.032). VPTs in CG and DM groups are significantly smaller than the DPN group, showing higher contrasts for the 30 Hz compared to the 200 Hz measurement. The correlations between fuzzy scores and VPTs confirm the relevance of using low and high frequencies to assess a comprehensive foot sensitivity status in people with DM. (AU)

• Processo FAPESP: 17/17848-3 - Efeitos do fortalecimento dos músculos dos pés na atividade física de vida diária e funcionalidade de tornozelo e pé de pessoas com polineuropatia diabética: um ensaio clínico controlado randomizado
• Beneficiário: Renan Lima Monteiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado