Magnetic and Highly Luminescent Heterostructures of Gd3+/ZnO Conjugated to GCIS/ZnS Quantum Dots for Multimodal Imaging

Autor(es)

da Silva, Bruna Lallo ^[1] ; Lemaire, Laurent ^{[2, 3]} ; Benoit, Jean-Pierre ^[2] ; Borges, Fernanda Hediger ^[4] ; Goncalves, Rogeria Rocha ^[4] ; Amantino, Camila Fernanda ^[1] ; Primo, Fernando Lucas ^[1] ; Chiavacci, Leila Aparecida ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, UNESP, Highway Araraquara Jau, BR-14800903 Araraquara, SP - Brazil

^[2] Univ Angers, SFR ICAT, CNRS, MINT, INSERM, F-49000 Angers - France

^[3] Univ Angers, PRISM, SFR ICAT, F-49000 Angers - France

^[4] Univ Sao Paulo, Dept Quim, FFCLRP, Lab Mat Luminescentes Micro & Nanoestruturados Ma, BR-14040901 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NANOMATERIALS; v. 11, n. 7 JUL 2021.
• Citações Web of Science: 0

Resumo

In recent years, the use of quantum dots (Qdots) to obtain biological images has attracted attention due to their excellent luminescent properties and the possibility of their association with contrast agents for magnetic resonance imaging (MRI). In this study, Gd3+/ZnO (ZnOGd) were conjugated with Qdots composed of a gadolinium-copper-indium-sulphur core covered with a ZnS shell (GCIS/ZnS Qdots). This conjugation is an innovation that has not yet been described in the literature, and which aims to improve Qdot photoluminescent properties. Structural and morphological Qdots features were obtained by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analyses (TGA). The photoluminescent properties were examined by emission (PL) and excitation (PLE) spectra. A new ZnOGd and GCIS/ZnS (ZnOGd-GCIS/ZnS) nanomaterial was synthesized with tunable optical properties depending on the ratio between the two native Qdots. A hydrophilic or lipophilic coating, using 3-glycidyloxypropyltrimethoxysilane (GPTMS) or hexadecyltrimethoxysilane (HTMS) on the surface of ZnOGd-GCIS/ZnS Qdots, was carried out before assessing their efficiency as magnetic resonance contrast agents. ZnOGd-GCIS/ZnS had excellent luminescence and MRI properties. The new Qdots developed ZnOGd-GCIS/ZnS, mostly constituted of ZnOGd (75%), which had less cytotoxicity when compared to ZnOGd, as well as greater cellular uptake. (AU)

• Processo FAPESP: 18/14164-9 - Desenvolvimento de auto-montagens teranósticas baseadas em pontos quânticos e ferroceno
• Beneficiário: Bruna Lallo da Silva
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 17/21456-3 - Desenvolvimento de sistemas teranósticos híbridos
• Beneficiário: Leila Aparecida Chiavacci Favorin
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/16074-4 - Desenvolvimento de sistemas teranósticos a base de ZnO dopado com GD, Mn e Co e nanocápsulas lipídicas
• Beneficiário: Bruna Lallo da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado