Non-coding RNAs in Wilms' tumor: biological function, mechanism, and clinical implications

Autor(es)

de Sa Pereira, Bruna Maria ^[1] ; Montalvao de Azevedo, Rafaela ^{[1, 2]} ; da Silva Guerra, Joao Victor ^{[3, 4]} ; Faria, Paulo A. ^[1] ; Soares-Lima, Sheila Coelho ^[1] ; De Camargo, Beatriz ^[1] ; Maschietto, Mariana ^{[3, 5]}

Afiliação do(s) autor(es)

^[1] Brazilian Natl Canc Inst INCa, Rio De Janeiro, RJ - Brazil

^[2] Fdn IRCCS Ist Nazl Tumori, Res Dept, Mol Bases Genet Risk & Genet Testing Unit, Milan - Italy

^[3] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, Campinas, SP - Brazil

^[4] Univ Estadual Campinas, Fac Pharmaceut Sci, Postgrad Program Pharmaceut Sci, Campinas, SP - Brazil

^[5] Boldrini Childrens Hosp, Res Inst, Rua Dr Gabriel Porto, 1270 Cidade Univ, BR-13083210 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF MOLECULAR MEDICINE-JMM; v. 99, n. 8, p. 1043-1055, AUG 2021.
• Citações Web of Science: 0

Resumo

Non-coding RNAs are involved with maintenance and regulation of physiological mechanisms and are involved in pathological processes, such as cancer. Among the small ncRNAs, miRNAs are the most explored in tumorigenesis, metastasis development, and resistance to chemotherapy. These small molecules of similar to 22 nucleotides are modulated during early renal development, involved in the regulation of gene expression and Wilms' tumor progression. Wilms' tumors are embryonic tumors with few mutations and complex epigenetic dysregulation. In recent years, the small ncRNAs have been explored as potentially related both in physiological development and in the tumorigenesis of several types of cancer. Besides, genes regulated by miRNAs are related to biological pathways as PI3K, Wnt, TGF-beta, and Hippo signaling pathways, among others, which may be involved with the underlying mechanisms of resistance to chemotherapy, and in this way, it has emerged as potential targets for cancer therapies, including for Wilms' tumors. (AU)

• Processo FAPESP: 14/10250-7 - Investigação da regulação epigenética em tumores sólidos pediátricos
• Beneficiário: Mariana Camargo Maschietto
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 15/06281-7 - Investigação da regulação epigenética em tumores sólidos pediátricos
• Beneficiário: Mariana Camargo Maschietto
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores