iocompatible gum arabic-gold nanorod composite as an effective therapy for mistreated melanoma

Autor(es):Mostrar menos -

Goncalves, Jenifer P. ^[1] ; da Cruz, Anderson F. ^[1] ; Nunes, Abner M. ^[2] ; Meneghetti, Mario R. ^[2] ; de Barros, Heloise R. ^{[3, 4]} ; Borges, Beatriz S. ^[5] ; de Medeiros, Lia C. A. S. ^[5] ; Soares, Maurilio J. ^[5] ; dos Santos, Mayara P. ^[6] ; Grassi, Marco T. ^[6] ; Rossi, Gustavo R. ^[1] ; Bellan, Daniel L. ^[1] ; Biscaia, Stellee M. P. ^[1] ; Cristal, Aline M. ^[1] ; Buzzo, Joao L. A. ^[1] ; Ribeiro, Yasmin C. ^[1] ; Acco, Alexandra ^[7] ; Cardoso, Mateus B. ^[8] ; Simas, Fernanda F. ^[1] ; Trindade, Edvaldo S. ^[1] ; Riegel-Vidotti, Izabel C. ^[3] ; de Oliveira, Carolina C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Parana UFPR, Sect Biol Sci, Cell Biol Dept, Lab Sulfated Polysaccharides Invest, Lab Inflammat, Av Cel Francisco H Dos Santos S-N, BR-81530980 Curitiba, Parana - Brazil

^[2] Univ Fed Alagoas, Inst Chem & Biotechnol, Catalysis & Chem React Grp, Av Lourival Melo Mota S-N, BR-57072900 Maceio, Alagoas - Brazil

^[3] UFPR, Dept Chem, Macromol & Interfaces Res Grp, Av Cel Francisco H dos Santos S-N, BR-81530980 Curitiba, Parana - Brazil

^[4] Univ Sao Paulo, Chem Inst, Lab Electroact Mat, Av Prof Lineu Prestes 748, BR-05513970 Sao Paulo, SP - Brazil

^[5] Inst Carlos Chagas ICC Fiocruz, Lab Cell Biol, Rua Prof Algacyr Munhoz Mader 3775, BR-81350010 Curitiba, Parana - Brazil

^[6] UFPR, Dept Chem, Environm Chem Grp, Av Cel Francisco H Dos Santos S-N, BR-81530980 Curitiba, Parana - Brazil

^[7] UFPR, Dept Pharmacol, Av Cel Francisco H Dos Santos S-N, BR-81530980 Curitiba, Parana - Brazil

^[8] Ctr Nacl Pesquisa Energia & Mat, Lab Nacl Luz Sincrotron, Rua Giuseppe Maximo Scolfaro 10000, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Macromolecules; v. 185, p. 551-561, AUG 31 2021.
• Citações Web of Science: 0

Resumo

Advanced melanoma patients that are not included in common genetic classificatory groups lack effective and safe therapeutic options. Chemotherapy and immunotherapy show unsatisfactory results and devastating adverse effects for these called triple wild-type patients. New approaches exploring the intrinsic antitumor properties of gold nanoparticles might reverse this scenario as a safer and more effective alternative. Therefore, we investigated the efficacy and safety of a composite made of gum arabic-functionalized gold nanorods (GA-AuNRs) against triple wild-type melanoma. The natural polymer gum arabic successfully stabilized the nanorods in the biological environment and was essential to improve their biocompatibility. In vivo results obtained from treating triple wild-type melanoma-bearing mice showed that GA-AuNRs remarkably reduced primary tumor growth by 45%. Furthermore, GA-AuNRs induced tumor histological features associated with better prognosis while also reducing superficial lung metastasis depth and the incidence of intrapulmonary metastasis. GA-AuNRs' efficacy comes from their capacity to reduce melanoma cells ability to invade the extracellular matrix and grow into colonies, in addition to a likely immunomodulatory effect induced by gum arabic. Additionally, a broad safety investigation found no evidence of adverse effects after GA-AuNRs treatment. Therefore, this study unprecedentedly reports GA-AuNRs as a potential nanomedicine for advanced triple wild-type melanomas. (AU)

• Processo FAPESP: 17/20892-4 - Catalisadores nanobioplasmônicos: uma nova abordagem para o controle da seletividade direcionada pela luz em reações one-pot
• Beneficiário: Heloise Ribeiro de Barros
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/25406-5 - Organizando a matéria: colóides formados por associação de surfactantes, polímeros e nanopartículas
• Beneficiário: Watson Loh
• Modalidade de apoio: Auxílio à Pesquisa - Temático