Impact of metabolic syndrome and its components on bone remodeling in adolescents

Autor(es)

Nobrega da Silva, Valeria ^[1] ; Goldberg, Tamara Beres Lederer ^[1] ; Silva, Carla Cristiane ^[2] ; Kurokawa, Cilmery Suemi ^[3] ; Fiorelli, Luciana Nunes Mosca ^[1] ; Rizzo, Anapaula da Conceicao Bisi ^[1] ; Corrente, Jose Eduardo ^[4]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Botucatu Med Sch, Postgrad Program Tocogynecol, Dept Pediat, Discipline Adolescent Med, UNESP, Botucatu, SP - Brazil

^[2] Univ North Parana, Dept Phys Educ, Jacarezinho, Parana - Brazil

^[3] Sao Paulo State Univ, UNESP, Clin & Expt Pediat Res Ctr, Dept Pediat, Botucatu Med Sch, Botucatu, SP - Brazil

^[4] Sao Paulo State Univ, UNESP, Dept Stat, Biosci, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 16, n. 7 2021.
• Citações Web of Science: 0

Resumo

Introduction Osteoporosis and metabolic syndrome (MetS) are diseases that have serious public health consequences, reducing the quality of life of patients and increasing morbidity and mortality, with substantial healthcare expenditures. Objective To evaluate the impact of MetS on bone mineral density (BMD) and biochemical markers of bone formation and resorption in adolescents with excess weight. Method A descriptive and analytical cross-sectional study was performed that evaluated 271 adolescents of both sexes (10 to 16 years). From the total sample, 42 adolescents with excess weight and the presence of MetS (14%) were selected. A further 42 adolescents with excess weight and without MetS were chosen, matched for chronological age, bone age, and pubertal developmental criteria to those with MetS, for each sex. Anthropometric measurements, blood pressure collection, and biochemical tests were performed in all adolescents, as well as evaluation of BMD and the bone biomarkers osteocalcin (OC), bone alkaline phosphatase (BAP), and carboxy-terminal telopeptide (S-CTx). Results The adolescents with excess weight and MetS exhibited significantly lower transformed BMD and concentrations of BAP, OC, and S-CTx compared to the matched group, except for OC in boys. A negative and significant correlation was observed between total body BMD and BAP (r = -0.55568; p = 0.005), OC (r = -0.81760; p = < .000), and S-CTx (r = -0.53838; p = 0.011) in girls. Conclusion Metabolic syndrome may be associated with reduced bone mineral density and biochemical markers of bone formation and resorption in adolescents with excess weight. (AU)

• Processo FAPESP: 07/07731-0 - Densidade e conteúdo mineral ósseo de adolescentes saudáveis do sexo feminino na faixa etária de 10 a 20 anos e suas relações com marcadores ósseos de formação e reabsorção
• Beneficiário: Tamara Beres Lederer Goldberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/04040-2 - Avaliação da densidade mineral óssea e de marcadores ósseos de adolescentes usuárias de anticoncepcionais hormonais de baixa dosagem (Etinil estradiol 20µg/Desogestrel 150g): 1 ano de acompanhamento
• Beneficiário: Tamara Beres Lederer Goldberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/05991-0 - O impacto do excesso de gordura corporal sobre a densidade mineral óssea e a remodelação óssea: estudo com adolescentes sobrepesos, obesos e superobesos (corrigido)
• Beneficiário: Tamara Beres Lederer Goldberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular