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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of metabolic syndrome and its components on bone remodeling in adolescents

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Author(s):
Nobrega da Silva, Valeria [1] ; Goldberg, Tamara Beres Lederer [1] ; Silva, Carla Cristiane [2] ; Kurokawa, Cilmery Suemi [3] ; Fiorelli, Luciana Nunes Mosca [1] ; Rizzo, Anapaula da Conceicao Bisi [1] ; Corrente, Jose Eduardo [4]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ, Botucatu Med Sch, Postgrad Program Tocogynecol, Dept Pediat, Discipline Adolescent Med, UNESP, Botucatu, SP - Brazil
[2] Univ North Parana, Dept Phys Educ, Jacarezinho, Parana - Brazil
[3] Sao Paulo State Univ, UNESP, Clin & Expt Pediat Res Ctr, Dept Pediat, Botucatu Med Sch, Botucatu, SP - Brazil
[4] Sao Paulo State Univ, UNESP, Dept Stat, Biosci, Botucatu, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PLoS One; v. 16, n. 7 2021.
Web of Science Citations: 0
Abstract

Introduction Osteoporosis and metabolic syndrome (MetS) are diseases that have serious public health consequences, reducing the quality of life of patients and increasing morbidity and mortality, with substantial healthcare expenditures. Objective To evaluate the impact of MetS on bone mineral density (BMD) and biochemical markers of bone formation and resorption in adolescents with excess weight. Method A descriptive and analytical cross-sectional study was performed that evaluated 271 adolescents of both sexes (10 to 16 years). From the total sample, 42 adolescents with excess weight and the presence of MetS (14%) were selected. A further 42 adolescents with excess weight and without MetS were chosen, matched for chronological age, bone age, and pubertal developmental criteria to those with MetS, for each sex. Anthropometric measurements, blood pressure collection, and biochemical tests were performed in all adolescents, as well as evaluation of BMD and the bone biomarkers osteocalcin (OC), bone alkaline phosphatase (BAP), and carboxy-terminal telopeptide (S-CTx). Results The adolescents with excess weight and MetS exhibited significantly lower transformed BMD and concentrations of BAP, OC, and S-CTx compared to the matched group, except for OC in boys. A negative and significant correlation was observed between total body BMD and BAP (r = -0.55568; p = 0.005), OC (r = -0.81760; p = < .000), and S-CTx (r = -0.53838; p = 0.011) in girls. Conclusion Metabolic syndrome may be associated with reduced bone mineral density and biochemical markers of bone formation and resorption in adolescents with excess weight. (AU)

FAPESP's process: 07/07731-0 - Bone mineral density and content in healthy female adolescents between 10 and 20 years old and their relationship with bone formation and reabsorption markers
Grantee:Tamara Beres Lederer Goldberg
Support Opportunities: Regular Research Grants
FAPESP's process: 15/04040-2 - Bone mineral density and bone biomarkers assessment in adolescents user of low-dose combined oral contraceptive (ethinylestradiol 20µg/Desogestrel 150µg): 1 year follow-up
Grantee:Tamara Beres Lederer Goldberg
Support Opportunities: Regular Research Grants
FAPESP's process: 11/05991-0 - The impact of body fat excess on bone densitometry and bone metabolims biomarkers: a study with overweight, obese and superobese adolescents
Grantee:Tamara Beres Lederer Goldberg
Support Opportunities: Regular Research Grants