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Bone mineral density and bone biomarkers assessment in adolescents user of low-dose combined oral contraceptive (ethinylestradiol 20µg/Desogestrel 150µg): 1 year follow-up

Grant number: 15/04040-2
Support type:Regular Research Grants
Duration: September 01, 2015 - August 31, 2017
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal researcher:Tamara Beres Lederer Goldberg
Grantee:Tamara Beres Lederer Goldberg
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers: Anapaula da Conceição Bisi Rizzo ; Cilmery Suemi Kurokawa

Abstract

Low-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. Objectives: This study aimed to evaluate bone mineral density (BMD), bone mineral content (BMC) and bone biomarkers in female adolescents taking a standard low-dose COC (ethinylestradiol 20 µg/desogestrel 150 µg) over a 1-year period and to compare their data with those of healthy adolescents from the same age group not taking COCs. Methods: This will be a non-randomized parallel-control study with a 1-year follow-up. Sixty-seven adolescents aged from 12 to 19 years, divided into COC users (n=41) taking 20 µg ethinylestradiol/150 µg desogestrel and COC non-user controls (n=26), will be evaluated by bone densitometry examinations [L1-L4 lumbar spine region, whole body and subtotal body] and these parameters will be correlated to bone biomarkers [Osteocalcin (OC), bone alkaline phosphatase (BAP), and C- terminal telopeptide (S-CTx)] at baseline and after 6 and 12 months. Comparisons between the groups at the study onset will be performed using the Mann-Whitney test, with the significance level fixed at 5% or p<0.05. Comparisons between the groups at the study onset and after 12 months will be based on variations in the median percentages for bone mass variables. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NOBREGA DA SILVA, VALERIA; GOLDBERG, TAMARA BERES LEDERER; SILVA, CARLA CRISTIANE; KUROKAWA, CILMERY SUEMI; FIORELLI, LUCIANA NUNES MOSCA; RIZZO, ANAPAULA DA CONCEICAO BISI; CORRENTE, JOSE EDUARDO. Impact of metabolic syndrome and its components on bone remodeling in adolescents. PLoS One, v. 16, n. 7 2021. Web of Science Citations: 0.
ANAPAULA DA CONCEIÇÃO BISI RIZZO; TAMARA BERES LEDERER GOLDBERG; TALITA POLI BIASON; CILMERY SUEMI KUROKAWA; CARLA CRISTIANE DA SILVA; JOSÉ EDUARDO CORRENTE; HELIO RUBENS CARVALHO NUNES. One-year adolescent bone mineral density and bone formation marker changes through the use or lack of use of combined hormonal contraceptives. Jornal de Pediatria, v. 95, n. 5, p. 567-574, Set. 2019. Web of Science Citations: 0.
MOSCA, L. N.; GOLDBERG, T. B. L.; DA SILVA, V. N.; KUROKAWA, C. S.; RIZZO, A. C. B.; DA SILVA, C. C.; DOS SANTOS TEIXEIRA, A.; CORRENTE, J. E. The impact of excess body fat on bone remodeling in adolescents. OSTEOPOROSIS INTERNATIONAL, v. 28, n. 3, p. 1053-1062, MAR 2017. Web of Science Citations: 0.
DA SILVA, VALERIA NOBREGA; MOSCA FIORELLI, LUCIANA NUNES; DA SILVA, CARLA CRISTIANE; KUROKAWA, CILMERY SUEMI; LEDERER GOLDBERG, TAMARA BERES. Do metabolic syndrome and its components have an impact on bone mineral density in adolescents?. NUTRITION & METABOLISM, v. 14, JAN 4 2017. Web of Science Citations: 9.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.