Introduction: The literature has sought to understand the effects of sports practice on health components, especially in pediatric populations aimed at reducing the risk of developing chronic diseases in adulthood. Impact sports, practiced during adolescence, have shown propulsive effects on the development of bone tissue, especially in bone mineral density. However, some modalities, such as athletics, although apparently covering the characteristics necessary to promote bone health (jumping, running, changes of direction, besides sun exposure), the literature is still scarce of information about the effect of the modality on bone health . Objective: To analyze the effect of athletic practice on the bone tissue, metabolic and inflammatory profile in adolescents of both sexes during a period of 12 months. Methods: This project, with a longitudinal observational design, aims to accompany adolescents during 12 months (baseline  and 12 months [i]), being conducted in the city of Presidente Prudente - SP. Sample will be composed of adolescents between 11 and 18 years old, divided into two distinct groups: I) Control (adolescents not practicing sports modalities systematized) and II) Athletic group (adolescents practicing athletics for at least 1 year). In addition to the other specific inclusion criteria that will be adopted for each group. Will be analyzed for study outcomes: I) Dependent Variable: Bone mineral density and bone mineral content, analyzed by dual energy x-ray absorptiometry (DXA); II) Independent Variable: i- anthropometric (weight, stature, fat mass, fat-free mass and bone), ii- Serum Variables (vitamin D, Calcium, Triglycerides, HDL, LDL, of Training Load; Confusion variable: i- age, ii- sex, iii - somatic maturation. Statistical significance will be set at p <0.05 and all analyzes will be performed using Stata 15.1 (Texas, USA).
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