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Bone mineral density and content in healthy female adolescents between 10 and 20 years old and their relationship with bone formation and reabsorption markers

Abstract

Osteoporosis is considered a serious public health problem and studies indicate it is a paediatric disease clinically manifesting in senility. Although these manifestations related to pictures of osteoporosis mainly occur in the elderly, their predisposition begins in infancy and adolescence, periods of maximum bone mineral capital increment. Therefore this study aims to evaluate some aspects of bone metabolism in female adolescents, together with indispensible knowledge for understanding them. For this 75 female adolescents will be recruited for the study of bone mineral content (BMC) and density (BMD) by bone densitometry using dual-energy x-ray absorptiometry (DXA), related to the levels and behaviour of some bone remodelling biochemical markers such as: osteocalcin, bone alkaline phosphatase, and sCTX. These biochemical markers, BMC, and BMD will be analyzed in age bands within the 10 to 20 incomplete years and associated with anthropomorphic data (weight, height, BMI), dietary evaluation, sexual maturity, and bone age. Data will be processed by analysis of variance to compare all age groups and maturation levels against BMC and BMD, and the Tukey test to locate significant differences adopting p lower than 5%. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NOBREGA DA SILVA, VALERIA; GOLDBERG, TAMARA BERES LEDERER; SILVA, CARLA CRISTIANE; KUROKAWA, CILMERY SUEMI; FIORELLI, LUCIANA NUNES MOSCA; RIZZO, ANAPAULA DA CONCEICAO BISI; CORRENTE, JOSE EDUARDO. Impact of metabolic syndrome and its components on bone remodeling in adolescents. PLoS One, v. 16, n. 7 2021. Web of Science Citations: 0.
ANAPAULA DA CONCEIÇÃO BISI RIZZO; TAMARA BERES LEDERER GOLDBERG; TALITA POLI BIASON; CILMERY SUEMI KUROKAWA; CARLA CRISTIANE DA SILVA; JOSÉ EDUARDO CORRENTE; HELIO RUBENS CARVALHO NUNES. Alterações na densidade mineral óssea e nos marcadores de formação óssea em adolescentes usuárias ou não de contraceptivos hormonais orais combinados por período de um ano. Jornal de Pediatria, v. 95, n. 5, p. 567-574, Set. 2019. Web of Science Citations: 0.
MOSCA, L. N.; GOLDBERG, T. B. L.; DA SILVA, V. N.; KUROKAWA, C. S.; RIZZO, A. C. B.; DA SILVA, C. C.; DOS SANTOS TEIXEIRA, A.; CORRENTE, J. E. The impact of excess body fat on bone remodeling in adolescents. OSTEOPOROSIS INTERNATIONAL, v. 28, n. 3, p. 1053-1062, MAR 2017. Web of Science Citations: 0.
DA SILVA, VALERIA NOBREGA; MOSCA FIORELLI, LUCIANA NUNES; DA SILVA, CARLA CRISTIANE; KUROKAWA, CILMERY SUEMI; LEDERER GOLDBERG, TAMARA BERES. Do metabolic syndrome and its components have an impact on bone mineral density in adolescents?. NUTRITION & METABOLISM, v. 14, JAN 4 2017. Web of Science Citations: 9.
DA SILVA, VALERIA NOBREGA; LEDERER GOLDBERG, TAMARA BERES; MOSCA, LUCIANA NUNES; BISI RIZZO, ANAPAULA DA CONCEICAO; TEIXEIRA, ALTAMIR DOS SANTOS; CORRENTE, JOSE EDUARDO. Metabolic syndrome reduces bone mineral density in overweight adolescents. BONE, v. 66, p. 1-7, SEP 2014. Web of Science Citations: 7.
MOSCA, LUCIANA NUNES; GOLDBERG, TAMARA BERES LEDERER; DA SILVA, VALERIA NOBREGA; DA SILVA, CARLA CRISTIANE; KUROKAWA, CILMERY SUEMI; BISI RIZZO, ANAPAULA C.; CORRENTE, JOSE EDUARDO. Excess body fat negatively affects bone mass in adolescents. NUTRITION, v. 30, n. 7-8, p. 847-852, JUL-AUG 2014. Web of Science Citations: 35.
CRISTINA MARIA TEIXEIRA FORTES; TAMARA BERES LEDERER GOLDBERG; CILMERY SUEMI KUROKAWA; CARLA CRISTIANI SILVA; MARIA REGINA MORETTO; TALITA POLI BIASON; ALTAMIR SANTOS TEIXEIRA; HÉLIO RUBENS DE CARVALHO NUNES. Relação entre as idades cronológica e óssea e o estágio puberal das mamas com os biomarcadores ósseos e a densidade mineral óssea em adolescentes. Jornal de Pediatria, v. 90, n. 6, p. 624-631, 2014-12-00.
DA SILVA, CARLA CRISTIANE; KUROKAWA, CILMERY SUEMI; NGA, HONG SI; MORETTO, MARIA REGINA; DALMAS, JOSE CARLOS; LEDERER GOLDBERG, TAMARA BERES. Bone metabolism biomarkers, body weight, and bone age in healthy Brazilian male adolescents. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v. 25, n. 5-6, p. 479-484, JUN 2012. Web of Science Citations: 4.
SILVA, CARLA C.; GOLDBERG, TAMARA B. L.; NGA, HONG S.; KUROKAWA, CILMERY S.; CAPELA, RENATA C.; TEIXEIRA, ALTAMIR S.; DALMAS, JOSE C. Impact of skeletal maturation on bone metabolism biomarkers and bone mineral density in healthy Brazilian male adolescents. Jornal de Pediatria, v. 87, n. 5, p. 450-456, SEP-OCT 2011. Web of Science Citations: 9.
SILVA, CARLA C.; GOLDBERG, TAMARA B. L.; TEIXEIRA, ALTAMIR S.; DALMAS, JOSE C. The impact of different types of physical activity on total and regional bone mineral density in young Brazilian athletes. JOURNAL OF SPORTS SCIENCES, v. 29, n. 3, p. 227-234, 2011. Web of Science Citations: 25.

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