Plasma metabolomics are associated with metabolic syndrome: A targeted approach

Autor(es)

Ferreira Carioca, Antonio Augusto ^{[1, 2]} ; Steluti, Josiane ^[1] ; de Carvalho, Aline Martins ^[1] ; Silva, Alexsandro Macedo ^[1] ; Guerreiro da Silva, Ismael Dale Cotrim ^[3] ; Fisberg, Regina Mara ^[1] ; Marchioni, Dirce Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil

^[2] Univ Fortaleza UNIFOR, Nutr Course, Fortaleza, Ceara - Brazil

^[3] Univ Fed Sao Paulo, Paulista Sch Med, Dept Gynecol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 83, MAR 2021.
• Citações Web of Science: 0

Resumo

Objectives: Advances in metabolomic tools have allowed us to gain a more comprehensive understanding of metabolic syndrome (MetS). The aim of this study was to evaluate the association between plasma metabolomic profiles and MetS. Methods: For this study, adults without diabetes, chronic kidney disease, stroke, heart disease, or cancer and with full metabolomics, biochemical, and dietetic data available, representing a subsample of the Health Survey of Sao Paulo study (ISA-Capital; N = 130), were included. The joint interim statement consensus criteria were used for diagnosing MetS. Absolute quantification (mmol/L) of blood metabolites was achieved by targeted quantitative profiling of annotated metabolites by electrospray ionization tandem mass spectrometry in plasma samples. Mean differences in the compounds for MetS were evaluated by linear regression adjusted for confounding factors. Results: Serine was inversely associated with MetS (beta = -15.04; P = 0.014). In glycerophospholipids with acyl-alkyl bonds, there was an inverse association with MetS, including phosphatidylcholine (PC) ae C42:5 (beta = -0.15; P = 0.040), PC ae C44:5 (beta = -0.15; P = 0.046), PC ae C40:4 (beta = -0.21; P = 0.014) and PC ae C44:4 (beta = -0.04; P = 0.032). Conclusion: Plasma metabolomic profiles were associated with MetS, especially the amino acid serine and some acyl-alkyl PCs. (C) 2020 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 09/15831-0 - Fatores dietéticos, homocisteína, polimorfismos do gene MTHFR e risco cardiovascular em adultos e idosos: estudo de base populacional - ISA - capital
• Beneficiário: Regina Mara Fisberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/16347-2 - Assinatura metabólica em migrantes e sua relação com padrões de consumo e síndrome metabólica: uma abordagem epidemiológica para elucidar os efeitos da dieta
• Beneficiário: Antonio Augusto Ferreira Carioca
• Modalidade de apoio: Bolsas no Brasil - Doutorado