Plasma metabolomics are associated with metabolic syndrome: A targeted approach

Author(s)

Ferreira Carioca, Antonio Augusto ^{[1, 2]} ; Steluti, Josiane ^[1] ; de Carvalho, Aline Martins ^[1] ; Silva, Alexsandro Macedo ^[1] ; Guerreiro da Silva, Ismael Dale Cotrim ^[3] ; Fisberg, Regina Mara ^[1] ; Marchioni, Dirce Maria ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil

^[2] Univ Fortaleza UNIFOR, Nutr Course, Fortaleza, Ceara - Brazil

^[3] Univ Fed Sao Paulo, Paulista Sch Med, Dept Gynecol, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: NUTRITION; v. 83, MAR 2021.
• Web of Science Citations: 0

Abstract

Objectives: Advances in metabolomic tools have allowed us to gain a more comprehensive understanding of metabolic syndrome (MetS). The aim of this study was to evaluate the association between plasma metabolomic profiles and MetS. Methods: For this study, adults without diabetes, chronic kidney disease, stroke, heart disease, or cancer and with full metabolomics, biochemical, and dietetic data available, representing a subsample of the Health Survey of Sao Paulo study (ISA-Capital; N = 130), were included. The joint interim statement consensus criteria were used for diagnosing MetS. Absolute quantification (mmol/L) of blood metabolites was achieved by targeted quantitative profiling of annotated metabolites by electrospray ionization tandem mass spectrometry in plasma samples. Mean differences in the compounds for MetS were evaluated by linear regression adjusted for confounding factors. Results: Serine was inversely associated with MetS (beta = -15.04; P = 0.014). In glycerophospholipids with acyl-alkyl bonds, there was an inverse association with MetS, including phosphatidylcholine (PC) ae C42:5 (beta = -0.15; P = 0.040), PC ae C44:5 (beta = -0.15; P = 0.046), PC ae C40:4 (beta = -0.21; P = 0.014) and PC ae C44:4 (beta = -0.04; P = 0.032). Conclusion: Plasma metabolomic profiles were associated with MetS, especially the amino acid serine and some acyl-alkyl PCs. (C) 2020 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 09/15831-0 - Dietary factors, homocystein, MTHFR gene polymorphisms, and cardiovascular risk in adults and the elderly: a population-based study - ISA - Capital
• Grantee: Regina Mara Fisberg
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/16347-2 - Metabolic signature on migrants and their relationship to patterns of consumption and metabolic syndrome: an epidemiological approach to elucidate the effects of diet
• Grantee: Antonio Augusto Ferreira Carioca
• Support Opportunities: Scholarships in Brazil - Doctorate