Metabolic signature on migrants and their relationship to patterns of consumption and metabolic syndrome: an epidemiological approach to elucidate the effects of diet

• Grant number: 14/16347-2
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): April 01, 2015
• Effective date (End): February 28, 2017
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal researcher: Dirce Maria Lobo Marchioni
• Grantee: Antonio Augusto Ferreira Carioca
• Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Observational studies have contributed to consolidate the idea that immigrants generally have different rates of morbidity and mortality than natives. Most studies have been focused on the effects of international migration since the risk factors tend to be more uniformly distributed within a single country. However, Brazil stands out for having extensive territory, regions with distinctive geographical, social and cultural differences and also different rates of mortality and morbidity from chronic diseases. Despite the clear role of the diet on modulating risk for chronic diseases, the scientific evidence are inconclusive and contradictory. The metabolic syndrome, which has become nowadays a serious public health problem, gathers with metabolic abnormalities, including dyslipidemia and insulin resistance, cardiovascular risk markers. The study named ISA Capital found that only one third of the population was born in São Paulo: thus, we propose to investigate whether the pattern of food consumption differs according to place of birth (internal migration), how this pattern is reflected in metabolic profile and its association with metabolic syndrome and its components, as well as its mediation by genetic variants related to the studied metabolic cycles. Innovative features such as metabolomics and multivariate data analysis, such as structural equation modeling (SEM) will be used. The metabolomics offers a potential in the area of nutritional assessment, by measuring the relative concentration of endogenous small molecules in biological fluids, which characterize changes in metabolism and helps to reveal the metabolic state of biological systems in response to the environment (internal and external); multivariate statistical technique has as a main objective to expand the explanatory ability to explain inter-related issues. Secondary data, already collected, will be used, from the Survey of Health of São Paulo (ISA-Capital 2008) will be using. This study has a cross-sectional, population-based, through a household survey design. Socioeconomic, dietary and biochemical data from 592 individuals will be used, and, for the metabolomic profile analysis by mass spectrometry, a subsample (n = 160), due to the high cost of analysis. It is hoped that this project, by bringing together perspectives enshrined in epidemiology (studies in migrants) with a comprehensive and innovative vision of food intake, metabolism and statistics, obtaining scientific evidence for the understanding of relevant issues in nutrition and health and to public health. It also has the advantage that, when using a secondary database, optimizes public resources already allocated previously. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA CARIOCA, ANTONIO AUGUSTO; STELUTI, JOSIANE; DE CARVALHO, ALINE MARTINS; SILVA, ALEXSANDRO MACEDO; GUERREIRO DA SILVA, ISMAEL DALE COTRIM; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Plasma metabolomics are associated with metabolic syndrome: A targeted approach. NUTRITION, v. 83, MAR 2021. Web of Science Citations: 0.

FERREIRA CARIOCA, ANTONIO AUGUSTO; GORGULHO, BARTIRA; FONTANELLI, MARIANE DE MELLO; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Cardiometabolic risk profile and diet quality among internal migrants in Brazil: a population-based study. EUROPEAN JOURNAL OF NUTRITION, v. 60, n. 2 MAY 2020. Web of Science Citations: 2.

MARCHIONI, DIRCE MARIA; DE OLIVEIRA, MAYARA FREITAS; FERREIRA CARIOCA, ANTONIO AUGUSTO; MACHADO MIRANDA, ANDREIA A.; CARVALHO, ALINE MARTINS; OKI, ERICA; NORDE, MARINA MAINTINGUER; ROGERO, MARCELO MACEDO; TEIXEIRA DAMASCENO, NAGILA RAQUEL; FISBERG, REGINA MARA. Plasma fatty acids: Biomarkers of dietary intake?. NUTRITION, v. 59, p. 77-82, MAR 2019. Web of Science Citations: 2.

NORDE, MARINA MAINTINGUER; OKI, ERICA; FERREIRA CARIOCA, ANTONIO AUGUSTO; TEIXEIRA DAMASCENO, NAGILA RAQUEL; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA; ROGERO, MARCELO MACEDO. Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study. Clinical Nutrition, v. 37, n. 2, p. 659-666, APR 2018. Web of Science Citations: 5.

FERREIRA CARIOCA, ANTONIO AUGUSTO; GORGULHO, BARTIRA; TEIXEIRA, JULIANA ARAUJO; FISBERG, REGINA MARA; MARCHIONI, DIRCE MARIA. Dietary patterns in internal migrants in a continental country: A population-based study. PLoS One, v. 12, n. 10 OCT 16 2017. Web of Science Citations: 1.

OKI, ERICA; NORDE, MARINA N.; CARIOCA, ANTONIO A. F.; SOUZA, JOSE M. P.; CASTRO, INAR A.; MARCHIONI, DIRCE M. L.; FISBERG, REGINA M.; ROGERO, MARCELO M. Polymorphisms of the TNF-alpha gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in Sao Paulo, Brazil. BRITISH JOURNAL OF NUTRITION, v. 117, n. 12, p. 1663-1673, JUN 2017. Web of Science Citations: 4.

DE CARVALHO, ALINE MARTINS; FERREIRA CARIOCA, ANTONIO AUGUSTO; FISBERG, REGINA MARA; QI, LU; MARCHIONI, DIRCE MARIA. Joint association of fruit, vegetable, and heterocyclic amine intake with DNA damage levels in a general population. NUTRITION, v. 32, n. 2, p. 260-264, FEB 2016. Web of Science Citations: 4.