Research Grants 22/09493-9 - Alimentos, Frutas - BV FAPESP
Advanced search
Start date
Betweenand

Metabolomic in vitro studies of fruit anthocyanins for understanding its mechanisms of action against Obesity

Grant number: 22/09493-9
Support Opportunities:Regular Research Grants
Start date: March 01, 2023
End date: February 28, 2025
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Juliano Lemos Bicas
Grantee:Juliano Lemos Bicas
Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers: Gonzalo Miyagusuku Cruzado ; Katia Sivieri ; Maria Monica Giusti ; Paulo Roberto de Araujo Berni ; Severino Matias de Alencar

Abstract

Overweight and obesity are a growing global problem that generates serious socioeconomic damage to public health systems. The recent pandemic COVID-19 brought a new concern about obesity since it is identified both as a risk factor for the disease and as a serious consequence of prolonged confinement. It is demonstrated that regular intake of purple-coloured fruits, so-called berries, rich in anthocyanins, directly promote the prevention of obesity, prevent weight gain, and combat the development of biochemical processes that initiate the installation of the metabolic syndrome. The anthocyanins, exert its anti-obesity activity through at least six biological activities: inhibition of lipid absorption; increased energy expenditure; stimulation of lipolytic metabolism; increased satiety; antioxidant and anti-inflammatory activity; and prebiotic effect. Despite the positive, prophylactic, and therapeutic effects that are observed in clinical studies, there are many events and interactions between anthocyanin intake and its anti-obesity action that are poorly understood. The phenomena involved in the digestion of anthocyanins, their stability, bioavailability, absorption, and interaction with the microbiota is not well comprehended. The present project proposes to broaden the understanding of the phenomena involved in the digestion of anthocyanins, their bioaccessibility, absorption, intracellular metabolism, interaction with the microbiota and anti-obesity action. Despite the recognized information that berry fruits are good for health, their consumption still low, and mostly anthocyanins in a common diet comes only from one or two different berries, like strawberry and blueberries. The decade for action in nutrition UN 2016 - 2025 reinforce the importance of investments in projects which promote healthy diets through production and consumption of local plant foods, such underexplored fruits. In this sense, there is a considerable diversity of fruits potentially rich in anthocyanins, which are an underexplored source of new foods, products, extracts, and compounds of economic and social interest. Therefore, in this project, we seek to investigate and value unconventional fruits that are sources of anthocyanins, reinforcing the body of evidence on their health benefits and disseminating their potential as new raw materials for healthy products. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NASCIMENTO, ROBERTO DE PAULA DO; RIZZATO, JULIA SOTO; POLEZI, GABRIELE; BOUGHANEM, HATIM; WILLIAMS, NON GWENLLIAN; BORGUINI, RENATA GALHARDO; SANTIAGO, MANUELA CRISTINA PESSANHA DE ARAUJO; MAROSTICA JUNIOR, MARIO ROBERTO; PARRY, LEE. Myrciaria jaboticaba Fruit Peel: Bioactive Composition as Determined by Distinct Harvest Seasons and In Vitro Anti-Cancer Activity. PLANTS-BASEL, v. 13, n. 20, p. 18-pg., . (22/10485-0, 22/09493-9, 19/03228-9, 20/00414-3)
CARNEIRO, MARA JUNQUEIRA; PINHEIRO, GUILHERME PEREZ; BASEGGIO, ANDRESSA MARA; MAROSTICA JR, MARIO ROBERTO; SAWAYA, ALEXANDRA CHRISTINE HELENA FRANKLAND. Chemical Composition and Antioxidant Activity of Essential Oil from Male and Female Schinus terebinthifolius. PHARMACOGNOSY RESEARCH, v. 15, n. 3, p. 8-pg., . (15/13320-9, 16/11524-9, 22/09493-9, 15/50333-1, 19/13465-8, 18/11069-5)
ARAUJO, NAYARA MACEDO PEIXOTO; BERNI, PAULO; ZANDONA, LAIS RAMALHO; DE TOLEDO, NATALY MARIA VIVA; DA SILVA, PAULA PORRELLI MOREIRA; DE TOLEDO, ANGELICA APARECIDA; MAROSTICA JUNIOR, MARIO ROBERTO. Potential of Brazilian berries in developing innovative, healthy, and sustainable food products. SUSTAINABLE FOOD TECHNOLOGY, v. 2, n. 3, p. 25-pg., . (22/09493-9, 21/02271-8)
MONROY, YANETH MACHACA; BERILLI, PATRICIA; FRAGA, SARA; SARTORATTO, ADILSON; RODRIGUES, MARILI VILLA NOVA; BARBERO, GERARDO FERNANDEZ; MEIRELLES, ANTONIO JOSE DE ALMEIDA; MAXIMO, GUILHERME JOSE; MAROSTICA JUNIOR, MARIO ROBERTO; SAMPAIO, KLICIA ARAUJO. Araçaúna ( Psidium myrtoides) flour: Sequential extraction with supercritical carbon dioxide and pressurized fluids. JOURNAL OF SUPERCRITICAL FLUIDS, v. 217, p. 11-pg., . (22/09493-9, 20/14683-6, 17/12015-3)
SILVA, JULIANA DARA RABELO; ARRUDA, HENRIQUE SILVANO; ANDRADE, AMANDA CRISTINA; BERILLI, PATRICIA; BORSOI, FELIPE TECCHIO; MONROY, YANETH MACHACA; RODRIGUES, MARILI VILLA NOVA; SAMPAIO, KLICIA ARAUJO; PASTORE, GLAUCIA MARIA; MAROSTICA JUNIOR, MARIO ROBERTO. Eugenia calycina and Eugenia stigmatosa as Promising Sources of Antioxidant Phenolic Compounds. PLANTS-BASEL, v. 13, n. 15, p. 16-pg., . (20/08761-4, 22/09493-9, 14/21252-0)
TAKEMURA, MIRIAM REGINA CANESIN; DA GRACA, JULIANA SILVA; FURTADO, MARIANNA MIRANDA; MARQUES, MARCELLA CAMARGO; SANT'ANA, ANDERSON S.; MAROSTICA JUNIOR, MARIO ROBERTO; MARIUTTI, LILIAN REGINA BARROS; GELONEZE, BRUNO; CAZARIN, CINTHIA BAU BETIM. Production of Long Fermentation Bread with Jabuticaba Peel Flour Added: Technological and Functional Aspects and Impact on Glycemic and Insulinemic Responses. FOODS, v. 13, n. 18, p. 17-pg., . (22/09493-9, 16/12001-0)
ALVES, MARIANA DA ROCHA; NASCIMENTO, ROBERTO DE PAULA; MACHADO, ANA PAULA DA FONSECA; DOS SANTOS, PHILIPE; ALEDO, EDUARDO; VUOLO, MILENA MORANDI; CAVALHEIRO, CAROLINA OLIVEIRA; GIACULI, VINICIUS OLIVEIRA; BERILLI, PATRICIA; DOS SANTOS, NATHALIA MEDINA; et al. Hop (Humulus lupulus L.) extract reverts glycaemic imbalance and cognitive impairment in an animal model of obesity. FOOD & FUNCTION, v. 15, n. 14, p. 12-pg., . (22/09493-9)
ADOLPHO, LETICIA FAUSTINO; GOMES, MARIA PAULA OLIVEIRA; FREITAS, GILEADE PEREIRA; BIGHETTI-TREVISAN, RAYANA LONGO; RAMOS, JAQUELINE ISADORA REIS; CAMPEOTI, GABRIELA HERNANDES; ZATTA, GUILHERME CREPI; ALMEIDA, ADRIANA LUISA GONCALVES; TARONE, ADRIANA GADIOLI; MAROSTICA-JUNIOR, MARIO ROBERTO; et al. Jaboticaba Peel Extract Attenuates Ovariectomy-Induced Bone Loss by Preserving Osteoblast Activity. BIOLOGY-BASEL, v. 13, n. 7, p. 12-pg., . (22/09493-9, 17/12622-7)
GERALDI, MARINA VILAR; DE SOUZA, AGATTA CAROLINE; NORDE, MARINA MAINTINGUER; BERNI, PAULO ROBERTO; REGUENGO, LIVIA MATEUS; GELONEZE, BRUNO; MAROSTICA, MARIO ROBERTO. Jaboticaba peel improves postprandial glucose and inflammation: A randomized controlled trial in adults with metabolic syndrome. Nutrition Research, v. 125, p. 14-pg., . (22/09493-9, 19/12244-8, 21/02271-8)