Full text
| |
| Author(s): |
Antonio Augusto Ferreira Carioca
Total Authors: 1
|
| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) |
| Defense date: | 2017-09-13 |
| Examining board members: |
Dirce Maria Lobo Marchioni;
Isabela Judith Martins Benseñor;
Sandra Patricia Crispim;
Maria do Rosario Dias de Oliveira Latorre;
Sandra Roberta Gouvea Ferreira Vivolo
|
| Advisor: | Dirce Maria Lobo Marchioni |
| Abstract | |
Introduction: Observational studies have helped consolidate the notion that immigrants generally exhibit different morbidity and mortality rates to those of natives. Studies involving immigrants can broaden understanding of the environmental influence on risk of chronic diseases. The majority of studies have focused on the effects of international migration, considering that risk factors tend to be uniformly distributed within a country. However, Brazil differs for its large territory comprising regions with marked geographic, social and cultural disparities. In countries of continental size (e.g. India and China), internal migration has been associated with changes in diet and health status. Objectives: To assess differences in dietary patterns and cardiometabolic risk among internal migrants and natives, and also to assess the association between plasma metabolomics and metabolic syndrome. Methods: A cross-sectional, population-based study was conducted in the city of São Paulo. The study involved internal migrants, defined as individuals born outside São Paulo city who had lived in the city for ten years or longer. The final population (n=999) was divided into three groups: natives of São Paulo (n=354), migrants from the Southeast (n=349) and from the Northeast (n=296). The harmonized criteria of the International Diabetes Federation were employed for metabolic syndrome diagnosis. Dietary patterns were derived by factor and principal component analysis. Absolute quantification (μmol/L) of blood metabolites was performed by mass spectrometry in plasma. Analyses were carried out based on generalized linear models adjusted for confounding factors. Results: Compared to locals, migrants from the Southeast had an inversely proportional adherence to the modern pattern whereas migrants from the Northeast had an inverse association with the prudent and modern patterns and a positive association with the traditional pattern. Northeastern migrants older than 60 years had greater odds of having the metabolic syndrome compared to São Paulo-born individuals of the same age. The plasma metabolomic profiles were associated with the metabolic syndrome, particularly for some aminoacids and lipid classes. Conclusion: São Paulo natives and internal migrants in Brazil have different consumption, dietary patterns and cardiovascular risk. Metabolomics detected metabolic changes secondary to metabolic syndrome. (AU) | |
| FAPESP's process: | 14/16347-2 - Metabolic signature on migrants and their relationship to patterns of consumption and metabolic syndrome: an epidemiological approach to elucidate the effects of diet |
| Grantee: | Antonio Augusto Ferreira Carioca |
| Support Opportunities: | Scholarships in Brazil - Doctorate |