Anterior cingulate cortex neuro-metabolic changes underlying lithium-induced euthymia in bipolar depression: A longitudinal H-1-MRS study

Autor(es)

Soeiro-de-Souza, M. G. ^[1] ; Scotti-Muzzi, E. ^[1] ; Fernandes, F. ^[1] ; De Sousa, R. T. ^[1] ; Leite, C. C. ^[2] ; Otaduy, M. C. ^[2] ; Machado-Vieira, R. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Sao Paulo - Brazil

^[2] Univ Sao Paulo InRad FMUSP, Lab Magnet Resonance LIM44, Dept & Inst Radiol, Sao Paulo - Brazil

^[3] Univ Texas, Austin, TX - USA

• Tipo de documento: Artigo Científico
• Fonte: European Neuropsychopharmacology; v. 49, p. 93-100, AUG 2021.
• Citações Web of Science: 0

Resumo

The diagnosis and treatment of bipolar depression (BDep) poses complex clinical challenges for psychiatry. Proton magnetic resonance spectroscopy (H-1-MRS) is a useful imaging tool for investigating in vivo levels of brain neuro-metabolites, critical to understanding the process of mood dysregulation in Bipolar Disorder. Few studies have evaluated longitudinal clinical outcomes in BDep associated with H-1-MRS metabolic changes. This study aimed to longitudinally assess brain H-1-MRS metabolites in the anterior cingulate cortex (ACC) correlated with improvement in depression (from BDep to euthymia) after lithium treatment in BDep patients versus matched healthy controls (HC). Twenty-eight medication-free BDep patients and 28 HC, matched for age and gender, were included in this study. All subjects were submitted to a 3-Tesla brain H-1-MRS scan in the ACC using a single-voxel (8cm(3)) PRESS sequence at baseline. At follow-up (6 weeks), 14 BDep patients repeated the exam in euthymia. Patients with current BDep had higher baseline Myo-inositol/Cr (mI/Cr) and Choline/Cr (Cho/Cr) compared to HC. After six weeks, mI/Cr or Cho/Cr levels in subjects that achieved euthymia no longer differed to levels in HC, while high Cho/Cr levels persisted in non-responders . Elevated ACC mI/Cr and Cho/Cr in BDep might indicate increased abnormal membrane phospholipid metabolism and phosphatidylinositol (PI) cycle activity. Return of mI/Cr and Cho/Cr to normal levels after lithium-induced euthymia sug-gests a critical regulatory effect of lithium targeting the PI cycle involved in mood regulation. (C) 2021 Elsevier B.V. and ECNP. All rights reserved. (AU)

• Processo FAPESP: 10/12286-8 - Estudo genético de associação entre polimorfismos de nucleotídeo único e desempenho cognitivo em pacientes bipolares tipo I jovens: Licavalgene: processo associado 2010/06230-0
• Beneficiário: Márcio Gerhardt Soeiro-de-Souza
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 12/23796-2 - "Estudo genético de associação entre desempenho neurocognitivo, polimorfismos de GAD1 e Reelina e espectroscopia por ressonância magnética 3T de Glutamato/GABA no transtorno bipolar tipo I e controles saudáveis"
• Beneficiário: Márcio Gerhardt Soeiro-de-Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado